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Prostate Cancer
Volume 2012 (2012), Article ID 452795, 8 pages
http://dx.doi.org/10.1155/2012/452795
Clinical Study

Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy

1Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, Greece
2Department of Pathology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, Greece
3Department of Urology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, Greece
4Department of Medicine, Institut Gustave Roussy, 94805 Villejuif, France
5Centre Pluridisciplinaire d'Oncologie, Centre Hospitalier Universitaire Vaudois, 1101Lausanne, Switzerland
6Department of Biomathematics, University of Thessaly School of Medicine, 41222 Larissa, Greece
7Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA

Received 30 January 2012; Accepted 27 February 2012

Academic Editor: Fazlul H. Sarkar

Copyright © 2012 Panagiotis J. Vlachostergios et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations. Membranous expression of NEP ( 𝑃 < 0 . 0 0 1 ), cytoplasmic ET-1 ( 𝑃 = 0 . 0 0 2 ), and cytoplasmic NFκB ( 𝑃 < 0 . 0 0 1 ) were correlated with time to PSA relapse. NEP was associated with ET-1 ( 𝑃 < 0 . 0 0 1 ) and NFκB ( 𝑃 < 0 . 0 0 1 ). ET-1 was also correlated with NFκB ( 𝑃 < 0 . 0 0 1 ). NEP expression ( 𝑃 = 0 . 0 1 7 ), pT stage ( 𝑃 = 0 . 0 1 3 ), and SMs ( 𝑃 = 0 . 0 3 6 ) were independent predictors of time to PSA recurrence. Conclusions. There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.