Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy

Table 1

Patients’ clinicopathological characteristics (𝑛=70) and associations with time to PSA relapse.

Characteristic	Subgroup	𝑛(%)	𝑃
Age (years)	≤65	31 (44.3)	0.277
range 47–75	>65	39 (55.7)
pre-op PSA (ng/mL)	<10	60 (85.7)	0.143
range 2.8–23.9	≥10	10 (14.3)
pT stage	≤2	42 (60.0)	<0.001
	≥3	28 (40.0)
Gleason score	≤7 (3 + 4)	50 (46.8)	<0.001
	≥7 (4 + 3)	20 (44.2)
SMs	(−)	49 (70.0)	0.004
	(+)	21 (30.0)
LN status	N0	53 (75.7)	0.072
	N1	6 (8.6)
	Nx	11 (15.7)

Pre-op PSA: preoperative PSA; pT stage: pathologic TNM stage; SMs: surgical margins; LN: lymph node; 𝑛: number of patients; 𝑃: statistical value.