Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy
Table 2
Correlations between levels of NEP, ET-1, NFκB expression, and clinicopathological characteristics.
Characteristic
NEP
ET-1
NFκB
low
high
low
high
low
high
(%)
(%)
(%)
(%)
(%)
(%)
Pre-op PSA
<10
28 (96.6)
34 (82.9)
0.076
32 (94.1)
30 (83.3)
0.277
35 (83.3)
27 (96.4)
0.191
≥10
1 (3.4)
7 (17.1)
2 (5.9)
6 (16.7)
7 (16.7)
1 (3.6)
Gleason score
≤7 (3 + 4)
20 (55.6)
30 (88.2)
0.003
19 (55.9)
31 (86.1)
0.008
37 (74)
6 (30)
0.001
≥7 (4 + 3)
16 (44.4)
4 (11.8)
15 (44.1)
5 (13.9)
13 (26)
14 (70)
pT stage
≤2
17 (47.2)
25 (73.5)
0.030
14 (41.2)
28 (77.8)
0.003
32 (76.2)
11 (39.3)
0.003
≥3
19 (52.8)
9 (26.5)
20 (58.8)
8 (22.2)
10 (23.8)
17 (60.7)
SMs
(−)
22 (61.1)
27 (79.4)
0.121
20 (58.8)
29 (80.6)
0.068
33 (76.7)
16 (59.3)
0.180
(+)
14 (38.9)
7 (20.6)
14 (41.2)
7 (19.4)
10 (23.3)
11 (40.7)
Pre-op PSA: preoperative PSA; pT stage: pathologic TNM stage; SMs: surgical margins; number of patients; statistical value.
