Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy

Table 4

Multivariate Cox regression analysis.

Variable	Groups	HR [95% CI]	𝑃
NEP	low vs high	4.386 [1.305–14.706]	0.017
ET-1	low vs high	0.636 [0.167–2.422]	0.507
NFκB	low vs high	0.851 [0.273–2.652]	0.781
pre-op PSA	<10 vs ≥10	0.334 [0.101–1.097]	0.071
Gleason score	≤7 (3 + 4) vs ≥7 (4 + 3)	0.637 [0.276–1.473]	0.291
pT stage	≤2 vs ≥3	0.330 [0.137–0.795]	0.013
SMs	(−) vs (+)	0.485 [0.247–0.953]	0.036

pT stage: pathologic TNM stage; SMs: surgical margins; pre-op PSA: preoperative PSA; HR: hazard ratio; CI: confidence interval; 𝑃: statistical value; vs = versus.