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Prostate Cancer
Volume 2012 (2012), Article ID 524206, 4 pages
http://dx.doi.org/10.1155/2012/524206
Research Article

Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

1Department of Endocrinology, Stratton VA Medical Center, Albany, NY 12208, USA
2IT Department, Stratton VA Medical Center, Albany, NY 12208, USA
3Department of Research, Stratton VA Medical Center, Albany, NY 12208, USA

Received 19 October 2012; Revised 25 November 2012; Accepted 27 November 2012

Academic Editor: Manfred P. Wirth

Copyright © 2012 Subhashini Yaturu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prostate cancer (PCa) is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor. In this retrospective study, we compared vitamin D levels in subjects with PCa with those of age-matched men without PCa. Study subjects included 479 in each group with a mean age of 73 and a mean creatinine of 1.05 and 1.15. Levels of 25 (OH) vitamin D were and in subjects with and without PCa. Levels of 1,25 (OH) vitamin D were and in subjects with and without PCa. In contrast to other studies, we did not find a significant difference in vitamin D levels. Among prostate cancer patients, vitamin D levels correlated positively with age ( , ), and were negatively associated with BMI ( , ), glucose ( , ), HbA1C ( , ), and PTH ( ; ). The data do not show the causal effect of vitamin D levels on PCa.