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Prostate Cancer
Volume 2012 (2012), Article ID 543970, 13 pages
http://dx.doi.org/10.1155/2012/543970
Research Article

Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity

1The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
2Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA

Received 12 June 2012; Revised 24 October 2012; Accepted 24 October 2012

Academic Editor: J. W. Moul

Copyright © 2012 Melissa J. L. Bonorden et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To clarify effects of diet and body weight on prostate cancer development, three studies were undertaken using the TRAMP mouse model of this disease. In the first experiment, obesity was induced by injection of gold thioglucose (GTG). Age of prostate tumor detection (~33 wk) and death (~43 wk) was not significantly different among the groups. In the second study, TRAMP-C2 cells were injected into syngeneic C57BL6 mice and tumor progression was evaluated in mice fed either high-fat or low-fat diets. The high fat fed mice had larger tumors than did the low-fat fed mice. In the third study, tumor development was followed in TRAMP mice fed a high fat diet from 6 weeks of age. There were no significant effects of body weight status or diet on tumor development among the groups. When the tumors were examined for the neuroendocrine marker synaptophysin, there was no correlation with either body weight or diet. However, there was a significant correlation of the expression of synaptophysin with earlier age to tumor detection and death. In summary, TRAMP-C2 cells grew faster when the mice were fed a high-fat diet. Further synaptophysin may be a marker of poor prognosis independent of weight and diet.