Table 4: Overview of findings from the three studies.

Final body weights of GTG-obese mice were similar regardless of age at GTG injection.   Body and fat pad weights of GTG-obese mice were substantially heavier than GTG-lean or PBS-controls. TRAMP GTG GUT weights were not significantly different among the groups. Body weight did not significantly influence age of prostate tumor detection or age at death.   In the 6-week cohort GTG-lean mice tended to have higher rates of poorly differentiated tumors than GTG-lean or PBS-controls.   Reduced rates of metastases were observed in obese mice.   At 25 weeks of age body weights of the high-fat fed obesity-resistant mice were lower than the low-fat fed group. TRAMP-C2 DIO Tumors from high-fat fed mice were significantly heavier and had significantly larger volumes compared to the low-fat fed mice. When body weight was considered the differences in tumor weight and volume were no longer significantly different between any of the groups.   GUT and prostates from high-fat fed obesity-prone mice were significantly heavier than the other groups.   Neither body weight nor diet significantly influenced age to tumor detection.   Tumor differentiation was not significantly different between the groups. TRAMP DIO NE status did not differ between groups regardless of body weight or diet.   NE positive tumors were significantly related to younger age at tumor detection and younger age at death except for in the obesity-resistant groups where there was only a trend.   All NE positive tumors were poorly differentiated.