593241.fig.004a
(a)
593241.fig.004b
(b)
Figure 4: Conventional PCa (Gleason ) detected in a needle biopsy. Chromogranin A (CGA) immunohistochemistry reveals extensive neuroendocrine (NE) differentiation, which presents a multidrug-resistant phenotype in PCa (a). Immunohistochemical detection of somatostatin receptors in NE PCa cells (b) provides a therapeutic target for somatostatin analogues. Original magnifications: (a) (×100), (b) (×300).