Table 2: Differentially expressed microRNAs reported to be prognostic for prostate cancer.

TargetRole in prostate cancerPrognostic role

MiR-15/16 [4749]BCL2, CCDN1, WNT3A, also fibroblast growth factor-2 in tumor stromaDownregulated cell survival, proliferation, invasionIndirect: 13q del progression

MiR-21 [5052]Inhibits PTEN, PDCD4, TPM1, MARCKSDown regulated invasion and migrationBCR

MiR-23 [53]Repressed by MYCDown regulated mitochondrial activity

miR-25 [54]Cluster with miR-106b, inhibits PTENOverexpression tumorigenesis

miR-31 [55]Inhibits radixinDown regulated invasionGleason

miR-32 [54]Homologue of miR-25, inhibits Bim, pro-apoptotic geneOverexpression cell survivalEPE

miR-34 [56, 57]Target of p53Down regulated P53 mediated apoptosis disrupted. May affect cancer stem cells

miR-96 [55]Inhibits hZIP1Overexpression decrease zinc uptakeGleason

miR-100 [47, 58]THAP2 regulates cell cycle, SMARCA5 DNA replication, BAZ2A inhibits DNA replicationDecreased progression
Increased BCR

miR-125b [55]Inhibits BAK1Inhibits apoptosisStage

miR-135b [59]Inhibits mismatch repair gene MSH2Overexpression genomic instabilityBCR

miR-145 [6062]Inhibits c-MYCUpregulated or downregulatedGleason

miR-194 [59]Inhibits de novo methyltransferase DNMT3aOverexpression hypomethylation, genomic instabilityBCR

miR-196a [54]HoxB8Overexpression cell survivalEPE

miR-205 [55]Inhibits Laminin 5β3, SIP1, ZEPDownregulation invasionGleason, stage

miR-221/222 [55]Inhibit p27, p57, PTEN; stimulated by NF- 𝜅 BOverexpression cell survival and proliferationStage