Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer

Table 4

Cox regression model—GU grade 2 or higher^*.

	Univariate analysis			Multivariate analysis
	HR	(95% CI)	𝑃	HR	(95% CI)	𝑃
Age at diagnosis, continuous	1.03	(0.96–1.11)	0.381	1.03	(0.96–1.12)	0.388
Risk group
Low risk	1.00	(ref.)	—	1.00	(ref.)	—
Intermediate risk	2.07	(0.88–4.86)	0.094	1.90	(0.79–4.52)	0.149
High risk	1.05	(0.40–2.73)	0.921	0.91	(0.34–2.42)	0.850
Smoker
No	1.00	(ref.)	—	1.00	(ref.)	—
Yes	0.94	(0.36–2.45)	0.900	1.04	(0.38–2.81)	0.943
Diabetic
No	1.00	(ref.)	—	1.00	(ref.)	—
Yes	0.82	(0.25–2.69)	0.738	0.84	(0.24–2.90)	0.783
TUR-P
No	1.00	(ref.)	—	1.00	(ref.)	—
Yes	2.40	(0.73–7.91)	0.152	2.00	(0.55–7.18)	0.290
log-PTV proton volume, continuous	2.49	(0.80–7.90)	0.116	2.88	(0.76–7.80)	0.135

^*Only including patients with GU grade 0 at baseline and not missing information on smoking, diabetes, TUR-P, and PTV volume (𝑁=117).