Hypofractionated Proton Boost Combined with External Beam Radiotherapy for Treatment of Localized Prostate Cancer

Table 5

Cox regression model—GU grade 2 or higher^*.

	Univariate analysis			Multivariate analysis
	HR	(95% CI)	𝑃	HR	(95% CI)	𝑃
Age at diagnosis, continuous	0.97	(0.92–1.02)	0.249	0.97	(0.92–1.03)	0.276
Risk group
Low risk	1.00	(ref.)	—	1.00	(ref.)	—
Intermediate risk	0.89	(0.41–1.97)	0.781	1.01	(0.45–2.27)	0.988
High risk	0.60	(0.26–1.38)	0.228	0.58	(0.25–1.36)	0.212
Smoker
No	1.00	(ref.)	—	1.00	(ref.)	—
Yes	1.02	(0.51–2.02)	0.960	0.83	(0.40–1.71)	0.611
Diabetic
No	1.00	(ref.)	—	1.00	(ref.)	—
Yes	1.54	(0.68–3.46)	0.297	1.89	(0.82–4.39)	0.136
TUR-P
No	1.00	(ref.)	—	1.00	(ref.)	—
Yes	2.99	(0.91–9.81)	0.071	3.94	(1.12–13.88)	0.033
log-PTV proton volume, continuous	0.33	(0.13–0.84)	0.020	0.28	(0.10–0.76)	0.013

^*Only including patients with GU grade 1 at baseline and not missing information on smoking, diabetes, TUR-P, and PTV volume (𝑁=92).