Recent Trends in Prostate Cancer Incidence by Age, Cancer Stage, and Grade, the United States, 2001–2007

Table 2

Incidence rates and annual percentage changes in rates for prostate cancer by age, stage, and grade, US men over 40 years, 2001–2007.

	Count^1	%	Rate^2	95% CI		APC	95% CI
40–49 years
Stage^3
Localized	27,959	78.4	18.8	18.6	19.0	3.4	0.9	5.9
Regional	5,360	15.0	3.6	3.5	3.7	3.5	0.8	6.3
Distant	1,048	2.9	0.7	0.7	0.7	1.5	−1.2	4.3
Unstaged	1,279	3.6	0.9	0.8	0.9	−5.2	−12.5	2.7
Grade
Well differentiated, grade I	512	1.4	0.3	0.3	0.4	−24.3	−31.3	−16.6
Moder/poor/undifferentiated	34,161	95.8	22.9	22.7	23.2	3.8	1.7	5.9
Unknown	975	2.7	0.7	0.6	0.7	−6.8	−17.5	5.3
50–59 years
Stage^3
Localized	205,439	79.9	176.6	175.8	177.3	0.3	−2.3	3.1
Regional	36,709	14.3	31.6	31.3	31.9	0.8	−1.2	2.8
Distant	5,542	2.2	4.8	4.6	4.9	−1.7	−2.7	−0.6
Unstaged	9,423	3.7	8.1	7.9	8.3	−7.9	−11.9	−3.7
Grade
Well differentiated, grade I	3,924	1.5	3.4	3.3	3.5	−24.2	−27.5	−20.7
Moder/poor/undifferentiated	246,555	95.9	211.9	211.1	212.8	0.9	−1.3	3.1
Unknown	6,641	2.6	5.7	5.6	5.9	−12.9	−21.8	−3.1
60–69 years
Stage^3
Localized	386,583	81.3	564.1	562.3	565.9	−0.7	−3.3	2.0
Regional	55,990	11.8	81.2	80.5	81.9	0.8	−1.5	3.1
Distant	10,917	2.3	15.9	15.6	16.2	−2.0	−3.8	−0.1
Unstaged	22,120	4.7	32.4	32.0	32.9	−7.0	−11.1	−2.8
Grade
Well differentiated, grade I	8,600	1.8	12.6	12.3	12.9	−26.1	−27.7	−24.6
Moder/poor/undifferentiated	452,138	95.1	659.3	657.4	661.2	0.1	−2.1	2.4
Unknown	14,887	3.1	21.8	21.4	22.1	−12.7	−19.7	−5.2
70–79 years
Stage^3
Localized	342,813	83.7	751.2	748.7	753.7	−1.7	−3.8	0.4
Regional	22,923	5.6	49.9	49.3	50.6	−1.2	−3.9	1.6
Distant	13,226	3.2	29.1	28.6	29.6	−3.5	−5.5	−1.5
Unstaged	30,498	7.4	67.1	66.3	67.8	−9.0	−13.3	−4.6
Grade
Well differentiated, grade I	9,157	2.2	20.1	19.7	20.5	−26.3	−27.8	−24.7
Moder/poor/undifferentiated	382,224	93.3	837.5	834.8	840.2	−1.2	−3.1	0.8
Unknown	18,079	4.4	39.7	39.1	40.3	−13.4	−18.5	−7.9
80+ years
Stage^3
Localized	98,414	74.7	402.5	399.9	405.0	−2.7	−4.0	−1.4
Regional	5,080	3.9	21.0	20.5	21.6	−4.8	−7.3	−2.2
Distant	10,577	8.0	44.4	43.5	45.2	−4.6	−6.2	−2.8
Unstaged	17,748	13.5	73.7	72.6	74.8	−13.1	−17.9	−8.0
Grade
Well differentiated; grade I	3,354	2.5	13.8	13.3	14.3	−27.0	−28.1	−25.8
Moder/poor/undifferentiated	118,070	89.6	484.3	481.5	487.1	−3.1	−4.3	−2.0
Unknown	10,396	7.9	43.5	42.6	44.3	−10.8	−14.9	−6.4

APC: annual percentage change, CI: confidence interval, moder/poor/undifferentiated: moderately, poorly, or undifferentiated.
¹Data are from 46 population-based cancer registries that participate in the National Program of Cancer Registries (NPCR) and/or the Surveillance, Epidemiology, and End Results (SEER) Program and meet high quality data criteria. These registries cover 93.5% US population for 2004–2007.
²Rates are per 100,000 men and are age-adjusted to the 2000 US standard population.
³Sum of counts is less than total due to missing information on stage.