Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men
Table 2
Frequency of genotypes among South African and Senegalese prostate cancer cases and controls.
South Africa
Senegal
Genotypes
White
Mixed
Black
Combined
Senegalese
Genes
Controls (4)
Cases ()
Controls ()
Cases ()
Controls ()
Cases ()
Controls ()
Cases ()
‡Controls ()
‡Cases ()
CYP3A4 (rs2740574)
AA
122 (91.0%)
84 (70.0%)
117 (70.1%)
82 (39.6%)
2 (10.0%)
9 (36.0%)
241 (75.1%)
175 (49.7%)
21 (7.5%)
6 (7.1%)
AG
12 (9.0%)
34 (28.3%)
49 (29.3%)
111 (53.6%)
15 (75.0%)
16 (64.0%)
76 (23.7%)
161 (45.7%)
91 (32.3%)
40 (47.6%)
GG
0 (0%)
2 (1.7%)
1 (0.6%)
14 (6.8%)
3 (15.0%)
0 (0%)
4 (1.2%)
16 (4.6%)
170 (60.3%)
38 (45.2%)
CYP3A5 (rs776746)
GG
113 (84.3%)
95 (79.2%)
58 (34.7%)
58 (28.0%)
1 (5.0%)
1 (4.0%)
172 (53.6%)
154 (43.8%)
14 (5.3%)
4 (5.1%)
AG
18 (13.4%)
22 (18.3%)
72 (43.1%)
106 (51.2%)
5 (25.0%)
5 (20.0%)
95 (29.6%)
133 (37.8%)
66 (25.1%)
20 (25.3%)
AA
3 (2.3%)
3 (2.5%)
37 (22.2%)
43 (20.8%)
14 (70.0%)
19 (76.0%)
54 (16.8%)
65 (18.4%)
183 (69.6%)
55 (69.6%)
SRD5A2 V89L (rs523349)
GG
56 (41.8%)
61 (50.8%)
96 (57.5%)
131 (63.3%)
5 (25.0%)
16 (64.0%)
157 (48.9%)
208 (59.1%)
26 (12.2%)
10 (14.1%)
CG
70 (52.2%)
51 (42.5%)
65 (38.9%)
71 (34.3%)
7 (35.0%)
7 (28.0%)
142 (44.2%)
129 (36.6%)
61 (28.5%)
10 (14.1%)
CC
8 (6.0%)
8 (6.7%)
6 (3.6%)
5 (2.4%)
8 (40.0%)
2 (8.0%)
22 (6.9%)
15 (4.3%)
127 (59.4%)
51 (71.8%)
SRD5A2 A49T (rs9282858)
GG
107 (79.8%)
90 (75.0%)
127 (76.0%)
120 (58.0%)
10 (50.0%)
17 (68.0%)
244 (76.0%)
227 (64.5%)
278 (100.0%)
75 (100.0%)
GA
27 (20.2%)
30 (25.0%)
40 (24.0%)
87 (42.0%)
10 (50.0%)
8 (32.0%)
77 (24.0%)
125 (35.5%)
0 (0%)
0 (0.0%)
, for each polymorphism when comparing across each of the respective population groups for cases or for controls. ‡Some participants had missing genotype data. The numbers and percentages shown are for the available information.
