Table 3: South African and Senegalese case-control genotype associations with prostate cancer (adjusted for age).

Variables of interestSouth AfricaSenegal
White MixedBlackSenegalese
GenotypesOR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)

CYP3A4 (rs2740574)
 AA1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
 AG3.32 (1.52–7.24)*3.38 (2.13–5.35)**0.21 (0.03–1.32)1.51 (0.52–4.38)
 GG 4.57 (1.63–12.85)0.94 (0.54–1.65)
 AG/GG3.63 (1.68–7.84)*3.74 (2.37–5.89)**0.18 (0.03–1.16)1.13 (0.40–3.22)

CYP3A5 (rs776746)
 GG1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
 AG1.14 (0.55–2.37)1.68 (1.02–2.76) 1.31 (0.36–29.51)0.98 (0.18–5.39)
 AA 1.14 (0.46–2.79)1.21 (0.89–1.64)1.65 (0.38–7.15)0.99 (0.50–1.99)
 AG/AA1.17 (0.59–2.32)1.61 (1.01–2.57) 2.21 (0.12–39.39)0.98 (0.24–3.97)

SRD5A2 V89L
(rs523349)
 GG1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
 CG0.71 (0.41–1.24)0.74 (0.48–1.16)0.26 (0.04–1.54)0.36 (0.12–1.07)
 CC 0.86 (0.49–1.50)0.78 (0.41–1.48)0.17 (0.040.66)*0.98 (0.60–1.59)
 CG/CC0.71 (0.41–1.22)0.73 (0.47–1.13)0.14 (0.030.66)*0.74 (0.30–1.86)

SRD5A2 A49T (rs9282858)
 GG1.00 (ref)1.00 (ref)1.00 (ref)1.00 (ref)
 AG1.02 (0.54–1.95)2.31 (1.453.68)**0.43 (0.11–1.69)
 AA
 AG/AA1.02 (0.54–1.95)2.31 (1.453.68)**0.43 (0.11–1.69)

—: too few/no genotypes to estimate ORs.
* .
** .