Table 5: Case-control genotype associations with prostate cancer by non-Black and Black men (adjusted for age).

Variables of interestNon–Black (South African Mixed and White)Black (South African Black and Senegalese)
GenotypesOR (95% CI)OR (95% CI)

CYP3A4 (rs2740574)
 AA1.00 (ref)1.00 (ref)
 AG3.58 (2.445.24)**0.80 (0.35–1.82)
 GG 5.16 (1.85–14.39) 0.65 (0.41–1.02)
 AG/GG3.95 (2.725.75)**0.59 (0.26–1.31)

CYP3A5 (rs776746)
 GG1.00 (ref)1.00 (ref)
 AG1.78 (1.23–2.58) 1.06 (0.24–4.63)
 AA 1.30 (1.00–1.69) 1.08 (0.57–2.02)
 AG/AA1.75 (1.25–2.45) 1.13 (0.32–3.98)

SRD5A2 V89L (rs523349)
 GG1.00 (ref)1.00 (ref)
 CG0.68 (0.48–0.96) 0.26 (0.110.61)*
 CC 0.79 (0.52–1.20)0.67 (0.460.97)*
 CG/CC0.67 (0.48–0.94) 0.38 (0.190.77)*

SRD5A2 A49T (rs9282858)
 GG1.00 (ref)1.00 (ref)
 AG1.88 (1.30–2.73) 1.40 (0.48–4.12)
 AA
 AG/AA1.88 (1.30–2.73) 1.40 (0.48–4.12)

—: too few/no genotypes to estimate ORs.
* .
** .