Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men

Table 5

Case-control genotype associations with prostate cancer by non-Black and Black men (adjusted for age).

Variables of interest	Non–Black (South African Mixed and White)	Black (South African Black and Senegalese)
Genotypes	OR (95% CI)	OR (95% CI)
CYP3A4 (rs2740574)
AA	1.00 (ref)	1.00 (ref)
AG	3.58 (2.44–5.24)**	0.80 (0.35–1.82)
GG	5.16 (1.85–14.39)	0.65 (0.41–1.02)
AG/GG	3.95 (2.72–5.75)**	0.59 (0.26–1.31)
CYP3A5 (rs776746)
GG	1.00 (ref)	1.00 (ref)
AG	1.78 (1.23–2.58)	1.06 (0.24–4.63)
AA	1.30 (1.00–1.69)	1.08 (0.57–2.02)
AG/AA	1.75 (1.25–2.45)	1.13 (0.32–3.98)
SRD5A2 V89L (rs523349)
GG	1.00 (ref)	1.00 (ref)
CG	0.68 (0.48–0.96)	0.26 (0.11–0.61)*
CC	0.79 (0.52–1.20)	0.67 (0.46–0.97)*
CG/CC	0.67 (0.48–0.94)	0.38 (0.19–0.77)*
SRD5A2 A49T (rs9282858)
GG	1.00 (ref)	1.00 (ref)
AG	1.88 (1.30–2.73)	1.40 (0.48–4.12)
AA	—	—
AG/AA	1.88 (1.30–2.73)	1.40 (0.48–4.12)

—: too few/no genotypes to estimate ORs.
* 𝑃<0.05.
** 𝑃<0.0041.