Postoperative Radiotherapy after Radical Prostatectomy: Indications and Open Questions

Table 3

Characteristics and results of retrospective reports on salvage RT.

First author	Year	No. Pats.	Median pre-RT-PSA (ng/mL)	HT (%)	Med. RT-dose (Gy)	RT technique	Followup (months)	bNED (%)
Anscher et al. [25]	2000	89	1.4	9	66.0	2 D/3 D	48	50 (4 y.)
Bernard et al. [26]	2010	364	0.6	0	64.8	2 D/3 D	72	50 (5 y.)
De Meerleer et al. [27]	2008	87	0.7	56	75.0	IMRT	30	67 (5 y.)
Do et al. [28]	2002	73	2.8	9	64.8	2 D	42	45 (10 y.)
King and Spiotto [29]	2008	84	0.45	57	70.0	2 D/3 D/IMRT	>60	58 (5 y.)
Loeb et al. [30]	2008	107	~0.7	0	63.0	IMRT	53	55 (7 y.)
MacDonald et al. [22]	2004	102	1.1	0	65.8	n.r.	50	38 (5 y.)
Neuhof et al. [20]	2007	171	1.1	29	60–66	3 D	39	35 (5 y.)
Pazona et al. [31]	2005	223	0.8	4.5	63	3 D	56	40 (5 y.)
Pisansky et al. [32]	2000	166	0.9	4	64.0	2 D/3 D	52	46 (5 y.)
Stephenson et al. [24]	2004	501	0.7	17	64.8	2 D/3 D/IMRT	45	45 (4 y.)
Stephenson et al. [9]	2007	1540	1.1	14	64.8	2 D/3 D/IMRT	53	32 (6 y.)
Trock et al. [17]	2008	160	0.7	0	66.5	2 D/3 D	72	89 (10 y. OS)
Van Der Poel et al. [33]	2008	41	2.15	7	60–70	n.r.	73	44 (10 y.)
Wiegel et al. [19]	2009	162	0.33	0	66.0	3 D	41	54 (3.5 y.)

RT: radiotherapy; HT: hormonal therapy; Med. RT dose: median total dose of radiation therapy; bNED: biochemical no evidence of disease; n.r.: not reported; 2 D: 2-dimensional treatment planning; 3D: 3-dimensional treatment planning; IMRT: intensity-modulated radiation therapy; OS: overall survival.