About this Journal Submit a Manuscript Table of Contents
Prostate Cancer
Volume 2013 (2013), Article ID 384594, 7 pages
http://dx.doi.org/10.1155/2013/384594
Research Article

Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study

1Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USA
2The Center for Equal Health, Tampa, FL 33612, USA
3Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USA
4Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA

Received 27 August 2013; Revised 30 October 2013; Accepted 31 October 2013

Academic Editor: James L. Gulley

Copyright © 2013 Ganna Chornokur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 ( , ) and rs4430796 ( , ); in EAM, CTBP2 rs4962416 ( , ). In addition, high BMI in AAM ( , ) and height in EAM ( , ) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM ( , ). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM.