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Volume 2013 (2013), Article ID 384594, 7 pages
Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study
1Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USA
2The Center for Equal Health, Tampa, FL 33612, USA
3Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USA
4Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
Received 27 August 2013; Revised 30 October 2013; Accepted 31 October 2013
Academic Editor: James L. Gulley
Copyright © 2013 Ganna Chornokur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- American Cancer Society, Cancer Facts & Figures for African Americans 2011-2012, American Cancer Society, Atlanta, Ga, USA, 2011.
- G. Chornokur, K. Dalton, M. E. Borysova, and N. B. Kumar, “Disparities at presentation, diagnosis, treatment, and survival in African American men, affected by prostate cancer,” Prostate, vol. 71, no. 9, pp. 985–997, 2011.
- I. J. Powell, “Epidemiology and pathophysiology of prostate cancer in African-American men,” Journal of Urology, vol. 177, no. 2, pp. 444–449, 2007.
- E. D. Crawford, “Epidemiology of prostate cancer,” Urology, vol. 62, no. 6, pp. 3–12, 2003.
- Z. Kote-Jarai, A. A. A. Olama, G. G. Giles et al., “Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study,” Nature Genetics, vol. 43, no. 8, pp. 785–791, 2011.
- M. L. Freedman, A. N. A. Monteiro, S. A. Gayther et al., “Principles for the post-GWAS functional characterization of cancer risk loci,” Nature Genetics, vol. 43, no. 6, pp. 513–518, 2011.
- C. A. Haiman, N. Patterson, M. L. Freedman et al., “Multiple regions within 8q24 independently affect risk for prostate cancer,” Nature Genetics, vol. 39, no. 5, pp. 638–644, 2007.
- V. L. Stevens, J. Ahn, J. Sun et al., “HNFIB and JAZFI genes, diabetes, and prostate cancer risk,” Prostate, vol. 70, no. 6, pp. 601–607, 2010.
- M. M. Shen and C. Abate-Shen, “Molecular genetics of prostate cancer: new prospects for old challenges,” Genes and Development, vol. 24, no. 18, pp. 1967–2000, 2010.
- C. Kooperberg, M. LeBlanc, J. Y. Dai, and I. Rajapakse, “Structures and assumptions: strategies to harness gene × gene and gene × environment interactions in GWAS,” Statistical Science, vol. 24, no. 4, pp. 472–488, 2009.
- M. C. Cornelis, A. Agrawal, J. W. Cole et al., “The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions,” Genetic Epidemiology, vol. 34, no. 4, pp. 364–372, 2010.
- D. S. Michaud, K. Augustsson, E. B. Rimm, M. J. Stampfer, W. C. Willet, and E. Giovannucci, “A prospective study on intake of animal products and risk of prostate cancer,” Cancer Causes and Control, vol. 12, no. 6, pp. 557–567, 2001.
- R. Sinha, Y. Park, B. I. Graubard et al., “Meat and meat-related compounds and risk of prostate cancer in a large prospective cohort study in the United States,” American Journal of Epidemiology, vol. 170, no. 9, pp. 1165–1177, 2009.
- E. L. Giovannucci, Y. Liu, M. F. Leitzmann, M. J. Stampfer, and W. C. Willett, “A prospective study of physical activity and incident and fatal prostate cancer,” Archives of Internal Medicine, vol. 165, no. 9, pp. 1005–1010, 2005.
- C. M. Friedenreich and I. Thune, “A review of physical activity and prostate cancer risk,” Cancer Causes and Control, vol. 12, no. 5, pp. 461–475, 2001.
- C. M. Friedenreich, S. E. McGregor, K. S. Courneya, S. J. Angyalfi, and F. G. Elliott, “Case-control study of lifetime total physical activity and prostate cancer risk,” American Journal of Epidemiology, vol. 159, no. 8, pp. 740–749, 2004.
- S. J. Freedland and E. A. Platz, “Obesity and prostate cancer: making sense out of apparently conflicting data,” Epidemiologic Reviews, vol. 29, no. 1, pp. 88–97, 2007.
- C. L. Ogden, M. M. Lamb, M. D. Carroll, and K. M. Flegal, “Obesity and socioeconomic status in adults: United States, 2005–2008,” NCHS Data Brief, no. 50, pp. 1–8, 2010.
- CDC, Health United States, 2011, 2012, http://www.cdc.gov/nchs/data/hus/hus11.pdf.
- M. A. Kirschner, N. Ertel, and G. Schneider, “Obesity, hormones, and cancer,” Cancer Research, vol. 41, no. 9, pp. 3711–3717, 1981.
- A. G. Renehan, M. Tyson, M. Egger, R. F. Heller, and M. Zwahlen, “Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies,” The Lancet, vol. 371, no. 9612, pp. 569–578, 2008.
- K. M. Waters, L. Le Marchand, L. N. Kolonel et al., “Generalizability of associations from prostate cancer genome-wide association studies in multiple populations,” Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 4, pp. 1285–1289, 2009.
- R. A. Eeles, Z. Kote-Jarai, G. G. Giles, et al., “Multiple newly identified loci associated with prostate cancer susceptibility,” Nature Genetics, vol. 40, no. 3, pp. 316–321, 2008.
- J. Gudmundsson, P. Sulem, V. Steinthorsdottir et al., “Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes,” Nature Genetics, vol. 39, no. 8, pp. 977–983, 2007.
- H. Liu, B. Wang, and C. Han, “Meta-analysis of genome-wide and replication association studies on prostate cancer,” Prostate, vol. 71, no. 2, pp. 209–224, 2011.
- J. Sun, L. Purcell, Z. Gao et al., “Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans,” Prostate, vol. 68, no. 7, pp. 691–697, 2008.
- J. Ahn, A. S. Kibel, J. Y. Park et al., “Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence,” Clinical Cancer Research, vol. 17, no. 5, pp. 1075–1081, 2011.
- B.-L. Chang, E. Spangler, S. Gallagher et al., “Validation of genome-wide prostate cancer associations in men of african descent,” Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 1, pp. 23–32, 2011.
- C. A. Haiman, G. K. Chen, W. J. Blot et al., “Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans,” PLoS Genetics, vol. 7, no. 5, Article ID e1001387, 2011.
- S. Hooker, W. Hernandez, H. Chen et al., “Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans,” Prostate, vol. 70, no. 3, pp. 270–275, 2010.
- S. Lindstrom, F. Schumacher, A. Siddiq et al., “Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers-results from BPC3,” PLoS ONE, vol. 6, no. 2, Article ID e17142, 2011.
- A. W. Hsing, L. C. Sakoda, and S. Chua Jr., “Obesity, metabolic syndrome, and prostate cancer,” The American Journal of Clinical Nutrition, vol. 86, no. 3, pp. s843–s857, 2007.
- C. Bingham and A. T. Hattersley, “Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor-1β,” Nephrology Dialysis Transplantation, vol. 19, no. 11, pp. 2703–2708, 2004.
- I. S. Haldorsen, M. Vesterhus, H. Ræder et al., “Lack of pancreatic body and tail in HNF1B mutation carriers,” Diabetic Medicine, vol. 25, no. 7, pp. 782–787, 2008.
- M. Nakayama, K. Nozu, Y. Goto et al., “HNF1B alterations associated with congenital anomalies of the kidney and urinary tract,” Pediatric Nephrology, vol. 25, no. 6, pp. 1073–1079, 2010.
- S. I. Berndt, J. Sampson, M. Yeager et al., “Large-scale fine mapping of the HNF1B locus and prostate cancer risk,” Human Molecular Genetics, vol. 20, no. 16, pp. 3322–3329, 2011.
- J. Sun, S. L. Zheng, F. Wiklund et al., “Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12,” Nature Genetics, vol. 40, no. 10, pp. 1153–1155, 2008.
- V. W. Setiawan, J. Haessler, F. Schumacher et al., “HNF1B and endometrial cancer risk: results from the page study,” PLoS ONE, vol. 7, no. 1, Article ID e30390, 2012.
- A. B. Spurdle, D. J. Thompson, S. Ahmed et al., “Genome-wide association study identifies a common variant associated with risk of endometrial cancer,” Nature Genetics, vol. 43, no. 5, pp. 451–455, 2011.
- L. W. Harries, J. R. B. Perry, P. McCullagh, and M. Crundwell, “Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer,” BMC Cancer, vol. 10, article 315, 2010.
- E. Weiderpass, W. Ye, H. Vainio, R. Kaaks, and H.-O. Adami, “Reduced risk of prostate cancer among patients with diabetes mellitus,” International Journal of Cancer, vol. 102, no. 3, pp. 258–261, 2002.
- P. Berstad, R. J. Coates, L. Bernstein et al., “A case-control study of body mass index and breast cancer risk in white and African-American women,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 6, pp. 1532–1544, 2010.
- M. Sarkissyan, Y. Wu, and J. V. Vadgama, “Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles,” Cancer, vol. 117, no. 16, pp. 3814–3823, 2011.
- S. Paliwal, R. C. Kovi, B. Nath, Y.-W. Chen, B. C. Lewis, and S. R. Grossman, “The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor,” Cancer Research, vol. 67, no. 19, pp. 9322–9329, 2007.
- G. Thomas, K. B. Jacobs, M. Yeager et al., “Multiple loci identified in a genome-wide association study of prostate cancer,” Nature Genetics, vol. 40, no. 3, pp. 310–315, 2008.