About this Journal Submit a Manuscript Table of Contents
Prostate Cancer
Volume 2013 (2013), Article ID 384594, 7 pages
http://dx.doi.org/10.1155/2013/384594
Research Article

Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study

1Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USA
2The Center for Equal Health, Tampa, FL 33612, USA
3Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USA
4Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA

Received 27 August 2013; Revised 30 October 2013; Accepted 31 October 2013

Academic Editor: James L. Gulley

Copyright © 2013 Ganna Chornokur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Cancer Society, Cancer Facts & Figures for African Americans 2011-2012, American Cancer Society, Atlanta, Ga, USA, 2011.
  2. G. Chornokur, K. Dalton, M. E. Borysova, and N. B. Kumar, “Disparities at presentation, diagnosis, treatment, and survival in African American men, affected by prostate cancer,” Prostate, vol. 71, no. 9, pp. 985–997, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. I. J. Powell, “Epidemiology and pathophysiology of prostate cancer in African-American men,” Journal of Urology, vol. 177, no. 2, pp. 444–449, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. E. D. Crawford, “Epidemiology of prostate cancer,” Urology, vol. 62, no. 6, pp. 3–12, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. Kote-Jarai, A. A. A. Olama, G. G. Giles et al., “Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study,” Nature Genetics, vol. 43, no. 8, pp. 785–791, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. M. L. Freedman, A. N. A. Monteiro, S. A. Gayther et al., “Principles for the post-GWAS functional characterization of cancer risk loci,” Nature Genetics, vol. 43, no. 6, pp. 513–518, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. C. A. Haiman, N. Patterson, M. L. Freedman et al., “Multiple regions within 8q24 independently affect risk for prostate cancer,” Nature Genetics, vol. 39, no. 5, pp. 638–644, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. V. L. Stevens, J. Ahn, J. Sun et al., “HNFIB and JAZFI genes, diabetes, and prostate cancer risk,” Prostate, vol. 70, no. 6, pp. 601–607, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. M. Shen and C. Abate-Shen, “Molecular genetics of prostate cancer: new prospects for old challenges,” Genes and Development, vol. 24, no. 18, pp. 1967–2000, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Kooperberg, M. LeBlanc, J. Y. Dai, and I. Rajapakse, “Structures and assumptions: strategies to harness gene × gene and gene × environment interactions in GWAS,” Statistical Science, vol. 24, no. 4, pp. 472–488, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. C. Cornelis, A. Agrawal, J. W. Cole et al., “The gene, environment association studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions,” Genetic Epidemiology, vol. 34, no. 4, pp. 364–372, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. S. Michaud, K. Augustsson, E. B. Rimm, M. J. Stampfer, W. C. Willet, and E. Giovannucci, “A prospective study on intake of animal products and risk of prostate cancer,” Cancer Causes and Control, vol. 12, no. 6, pp. 557–567, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Sinha, Y. Park, B. I. Graubard et al., “Meat and meat-related compounds and risk of prostate cancer in a large prospective cohort study in the United States,” American Journal of Epidemiology, vol. 170, no. 9, pp. 1165–1177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. E. L. Giovannucci, Y. Liu, M. F. Leitzmann, M. J. Stampfer, and W. C. Willett, “A prospective study of physical activity and incident and fatal prostate cancer,” Archives of Internal Medicine, vol. 165, no. 9, pp. 1005–1010, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. C. M. Friedenreich and I. Thune, “A review of physical activity and prostate cancer risk,” Cancer Causes and Control, vol. 12, no. 5, pp. 461–475, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. C. M. Friedenreich, S. E. McGregor, K. S. Courneya, S. J. Angyalfi, and F. G. Elliott, “Case-control study of lifetime total physical activity and prostate cancer risk,” American Journal of Epidemiology, vol. 159, no. 8, pp. 740–749, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. S. J. Freedland and E. A. Platz, “Obesity and prostate cancer: making sense out of apparently conflicting data,” Epidemiologic Reviews, vol. 29, no. 1, pp. 88–97, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. C. L. Ogden, M. M. Lamb, M. D. Carroll, and K. M. Flegal, “Obesity and socioeconomic status in adults: United States, 2005–2008,” NCHS Data Brief, no. 50, pp. 1–8, 2010. View at Scopus
  19. CDC, Health United States, 2011, 2012, http://www.cdc.gov/nchs/data/hus/hus11.pdf.
  20. M. A. Kirschner, N. Ertel, and G. Schneider, “Obesity, hormones, and cancer,” Cancer Research, vol. 41, no. 9, pp. 3711–3717, 1981. View at Scopus
  21. A. G. Renehan, M. Tyson, M. Egger, R. F. Heller, and M. Zwahlen, “Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies,” The Lancet, vol. 371, no. 9612, pp. 569–578, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. K. M. Waters, L. Le Marchand, L. N. Kolonel et al., “Generalizability of associations from prostate cancer genome-wide association studies in multiple populations,” Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 4, pp. 1285–1289, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. R. A. Eeles, Z. Kote-Jarai, G. G. Giles, et al., “Multiple newly identified loci associated with prostate cancer susceptibility,” Nature Genetics, vol. 40, no. 3, pp. 316–321, 2008. View at Publisher · View at Google Scholar
  24. J. Gudmundsson, P. Sulem, V. Steinthorsdottir et al., “Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes,” Nature Genetics, vol. 39, no. 8, pp. 977–983, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Liu, B. Wang, and C. Han, “Meta-analysis of genome-wide and replication association studies on prostate cancer,” Prostate, vol. 71, no. 2, pp. 209–224, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Sun, L. Purcell, Z. Gao et al., “Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans,” Prostate, vol. 68, no. 7, pp. 691–697, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Ahn, A. S. Kibel, J. Y. Park et al., “Prostate cancer predisposition loci and risk of metastatic disease and prostate cancer recurrence,” Clinical Cancer Research, vol. 17, no. 5, pp. 1075–1081, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. B.-L. Chang, E. Spangler, S. Gallagher et al., “Validation of genome-wide prostate cancer associations in men of african descent,” Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 1, pp. 23–32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. C. A. Haiman, G. K. Chen, W. J. Blot et al., “Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans,” PLoS Genetics, vol. 7, no. 5, Article ID e1001387, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Hooker, W. Hernandez, H. Chen et al., “Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans,” Prostate, vol. 70, no. 3, pp. 270–275, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Lindstrom, F. Schumacher, A. Siddiq et al., “Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers-results from BPC3,” PLoS ONE, vol. 6, no. 2, Article ID e17142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. A. W. Hsing, L. C. Sakoda, and S. Chua Jr., “Obesity, metabolic syndrome, and prostate cancer,” The American Journal of Clinical Nutrition, vol. 86, no. 3, pp. s843–s857, 2007. View at Scopus
  33. C. Bingham and A. T. Hattersley, “Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor-1β,” Nephrology Dialysis Transplantation, vol. 19, no. 11, pp. 2703–2708, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. I. S. Haldorsen, M. Vesterhus, H. Ræder et al., “Lack of pancreatic body and tail in HNF1B mutation carriers,” Diabetic Medicine, vol. 25, no. 7, pp. 782–787, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Nakayama, K. Nozu, Y. Goto et al., “HNF1B alterations associated with congenital anomalies of the kidney and urinary tract,” Pediatric Nephrology, vol. 25, no. 6, pp. 1073–1079, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. S. I. Berndt, J. Sampson, M. Yeager et al., “Large-scale fine mapping of the HNF1B locus and prostate cancer risk,” Human Molecular Genetics, vol. 20, no. 16, pp. 3322–3329, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Sun, S. L. Zheng, F. Wiklund et al., “Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12,” Nature Genetics, vol. 40, no. 10, pp. 1153–1155, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. V. W. Setiawan, J. Haessler, F. Schumacher et al., “HNF1B and endometrial cancer risk: results from the page study,” PLoS ONE, vol. 7, no. 1, Article ID e30390, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. A. B. Spurdle, D. J. Thompson, S. Ahmed et al., “Genome-wide association study identifies a common variant associated with risk of endometrial cancer,” Nature Genetics, vol. 43, no. 5, pp. 451–455, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. L. W. Harries, J. R. B. Perry, P. McCullagh, and M. Crundwell, “Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer,” BMC Cancer, vol. 10, article 315, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. E. Weiderpass, W. Ye, H. Vainio, R. Kaaks, and H.-O. Adami, “Reduced risk of prostate cancer among patients with diabetes mellitus,” International Journal of Cancer, vol. 102, no. 3, pp. 258–261, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Berstad, R. J. Coates, L. Bernstein et al., “A case-control study of body mass index and breast cancer risk in white and African-American women,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 6, pp. 1532–1544, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Sarkissyan, Y. Wu, and J. V. Vadgama, “Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles,” Cancer, vol. 117, no. 16, pp. 3814–3823, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Paliwal, R. C. Kovi, B. Nath, Y.-W. Chen, B. C. Lewis, and S. R. Grossman, “The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor,” Cancer Research, vol. 67, no. 19, pp. 9322–9329, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. G. Thomas, K. B. Jacobs, M. Yeager et al., “Multiple loci identified in a genome-wide association study of prostate cancer,” Nature Genetics, vol. 40, no. 3, pp. 310–315, 2008. View at Publisher · View at Google Scholar · View at Scopus