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Prostate Cancer
Volume 2013 (2013), Article ID 519436, 15 pages
http://dx.doi.org/10.1155/2013/519436
Review Article

Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers

Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428, Buenos Aires, Argentina

Received 20 May 2013; Revised 6 August 2013; Accepted 8 August 2013

Academic Editor: James L. Gulley

Copyright © 2013 Diego J. Laderach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A better understanding of multimolecular interactions involved in tumor dissemination is required to identify new effective therapies for advanced prostate cancer (PCa). Several groups investigated protein-glycan interactions as critical factors for crosstalk between prostate tumors and their microenvironment. This review both discusses whether the “galectin-signature” might serve as a reliable biomarker for the identification of patients with high risk of metastasis and assesses the galectin-glycan lattices as potential novel targets for anticancer therapies. The ultimate goal of this review is to convey how basic findings related to galectins could be in turn translated into clinical settings for patients with advanced PCa.