Global Patterns of Prostate Cancer Incidence, Aggressiveness, and Mortality in Men of African Descent

Table 2

International variation in prostate tumor characteristics in men of African descent.

Region	Location	Data source*	𝑁	Mean age at diagnosis (Yrs, range)	Median PSA (ng/mL, range)	Gleason score, %					Tumor stage, %
						≤5	6	7	8	9+	T1	T2	T3	T4
Africa	Dakar, Senegal	HBCC	114	68 (41–95)	59.5 (0.5–6,190)	39	18	19	20	4	19	35	30	16
	Accra, Ghana	PSS	689	69 (42–95)	52.0 (0.7–8,423)	68	12	8	6	6	15	42	21	22
	Cape Town, South Africa: Coloured	HBCC	207	67 (46–94)	19.3 (0.5–14,390)	20	31	21	12	16	29	30	19	22
	Cape Town, South Africa: Black	HBCC	23	70 (52–90)	37.2 (5–3,308)	22	11	11	33	22	25	20	25	30
Caribbean	Guyana	HBCS	169	74 (26–98)	NA	NA	NA	NA	NA	NA	91 (T1 + T2)		4	5
	Jamaica [40]	HBCS	529	71 (41–91)	30.7 (12–109)	1	37	32	19	11	NA	NA	NA	NA
	Jamaica [41]	HBCS	99	72 (50–90)	37.0 (1–2,100)	0	16	24	41	18	24	39	21	9
	Tobago	PBR	508	65 (40–79)	6.3 (0.3–18,330)	.5	46	41	6	6	NA	NA	NA	NA
UK	Greater London	HBCS	177	71 (48–87)	107.6 (1–2,463)	10	40	38	9	3	34	42	20	4
US	Northeast**	HBCC	879	59 (36–88)	5.9 (0.3–69)	2	51	40	5	3	38	35	27	0.6
	Southeast**	HBCC	727	61 (91.36)	6.4 (0–5,000)	8	36	37	8	10	35	51	13	0.6
	Midwest**	HBCC	533	69 (38–97)	7.0 (0–14,635)	2	24	54	10	10	63	32	5	0
	West**	PBCC, PCS, HRCC	1,474	74 (42–91)	NA	7	30	40	15	7	89 (T1 + T2)		10	0.5

*Study type: HBCC: hospital-based case-control; HBCS: hospital-based case series; HRCC: high risk (aggressive disease) case-control study; PBCC: population-based case-control; PBR: population-based cancer registry; PCS: prospective cohort study; PSS: population screening study.
**MADCaP Groups: Northeast: Philadelphia, Baltimore, Washington DC; Southeast: Louisville, Houston, San Antonio, Tampa, Wake Forest; Midwest: Cleveland, Detroit, Flint, St. Louis; West: Seattle, Los Angeles, San Francisco Bay Area. Data from other centers as described in methods; citations indicate data were taken from the literature only; NA: Not Available.