Table 2: (a) Blood level omega-3 polyunsaturated fatty acids versus total prostate risk random effect analysis model. (b) Blood level omega-3 polyunsaturated fatty acids versus total prostate risk subgroup analysis model (nested case control versus case control).
(a)

Groups Effect estimates and 95% confidence intervalPublication bias
Omega-3 derivatives Number of study valuedf value Point estimatesLower limitUpper limit valueBeggEgger

ALA1011.54890.24022.0651.1880.9551.4770.1230.2830.502
DHA1118.991100.04047.3430.8760.6851.1190.2900.4360.239
DHA1014.45090.10737.7160.9350.7331.1940.5910.2110.127
DPA63.88350.5660.0000.7560.5990.9550.0191.0000.540
EPA1114.741100.14232.1620.9710.7841.2040.7920.5330.671
EPA108.65690.4700.0001.0700.8981.2750.4460.2110.502
(DHA + DPA + EPA)*32.676250.13923.4920.9420.8341.0640.336
(DHA + EPA)*23.410190.22018.8401.0220.8871.1790.760
Total omega-3*47.526350.07726.3560.9950.8951.1070.929

(b)

Groups Effect estimates and 95% confidence intervalPublication bias
Omega-3 derivatives Number of study valuedf value Point estimatesLower limitUpper limit valueBeggEgger

ALA1011.54890.24022.0651.1880.9551.4770.1230.2830.502
Case control56.89340.14241.9711.2370.7352.0830.423
Nested case control54.61440.32913.3001.1910.9481.4960.132
DHA1118.991100.04047.3430.8760.6851.1190.2900.4360.239
Case control65.43350.3657.9720.7690.5581.0600.109
Nested case control511.21340.02464.3270.9420.6701.3250.733
DPA63.88350.5660.0000.7560.5990.9550.0191.0000.540
Case control21.12610.28911.1800.6200.2781.3820.243
Nested case control42.43330.4880.0000.7730.6050.9880.040
EPA1114.741100.14232.1620.9710.7841.2040.7920.5330.671
Case control64.60350.4660.0000.8510.6341.1430.285
Nested case control58.66140.07053.8181.0280.7571.3960.859

Interstudy heterogeneity was tested by Cochrane’s (Chi2) at a significance level of and quantified by , where % is considered to be evidence of substantial heterogeneity and ≥75%, considerable heterogeneity.
Interstudy variation adjusted (heterogeneous study removed from the pool of effect estimates).
*Generated from adjusted total effect estimates from each PUFA random effect analysis.