Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice
Figure 4
Tissue distribution of fluorescence signal. Tissues were excised at endpoint from animals given YC-27 800CW (column (a)) or PSMA 800CW (column (b)). Representative whole organs (liver, kidney, and tumors) were imaged on the Pearl Impulse and reviewed for residual fluorescence of each probe 24 h after intravenous administration. (c) Tissue sections (8 μm; frozen) were prepared from muscle, brain, intestine, lung, heart, liver, kidney, spleen, testes, epididymis, and tumors, 22Rv1 and PC3 M-LN4. Sections were imaged on Odyssey CLx (21 μm) and 800 nm signal intensity per pixel was plotted for both probes.
