Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice
Figure 6
Specificity of YC-27 800CW for tumor imaging in vivo. SCID Hairless mice implanted with 22Rv1 (right flank, white arrows) and PC3 M-LN4 (left flank) cells received intravenous injections of 0.25, 0.5, or 1.0 nmol YC27-800CW or 2-PMPA (2 μg) plus YC-27 800CW (0.5 nmol). (a) Animals were imaged intact after 24 hours, using Pearl Impulse; (b) 22Rv1 tumor sections from each animal at endpoint were imaged on Odyssey CLx; (c) signal intensity of each tumor was quantified and normalized to unit area. Intact animal images are presented in pseudocolor. All images are normalized to the same LUT. Odyssey CLx images for tumor sections are shown in green (800 nm) and red (700 nm) and standardized to the same LUT.
