Evidence Suggesting That Obesity Prevention Measures May Improve Prostate Cancer Outcomes Using Data from a Prospective Randomized Trial

Table 2

Cox regression unadjusted and adjusted hazard ratios for clinical factors predicting for the risk of receipt of sAST.

Clinical factor	Number of men	Univariate analysis		Multivariate analysis
		HR (95% CI)	𝑃 value	AHR (95% CI)	𝑃 value
Initial treatment
RT only	34	1.47 (0.74, 2.93)	0.27	2.30 (1.02, 5.18)	0.05
RT + AST	15	1.00 (Ref)	—	1.00 (Ref)	—
ACE-27 comorbidity score
None to minimal	39	1.00 (Ref)	—	1.00 (Ref)	—
Moderate to severe	10	1.32 (0.37, 4.72)	0.67	2.67 (0.60, 11.97)	0.20
Treatment × comorbidity score interaction	49	0.51 (0.11, 2.42)	0.39	0.14 (0.02, 1.05)	0.06
Age, yr	49	0.96 (0.91, 1.02)	0.17	0.97 (0.92, 1.04)	0.39
BMI, kg/m^2	49	1.07 (1.00, 1.14)	0.04	1.11 (1.04, 1.18)	0.002
2013 NCCN risk group
Low or intermediate risk	30	1.00 (Ref)	—	1.00 (Ref)	—
High risk	19	1.56 (0.87, 2.82)	0.14	2.01 (1.05, 3.83)	0.03
Percent positive biopsies	49	1.00 (0.99, 1.01)	0.68	1.01 (0.99, 1.02)	0.35

Abbreviations: BMI: body mass index, RT: radiation therapy, AST: androgen suppression therapy, sAST: salvage androgen suppression therapy, ACE: Adult Comorbidity Evaluation, IQR: interquartile range, HR: hazard ratio, and AHR: adjusted hazard ratio.