Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients

Figure 4

Profile of serum cytokines. Analysis of sequential serum samples at baseline (preimmunotherapy [preIT]), during infusions (post inf#), and postimmunotherapy (1 week postimmunotherapy [1W postIT], 1 month postimmunotherapy [1 M postIT], and one year postimmunotherapy [1Y postIT]) shows increased levels of IL-2, IFN-γ, GM-CSF, and IL-10 and meanratio of Th₁/Th₂ = [IL-2+IFNγ]/[IL-4+IL-10] shows a dominant Th₁ type response during aATC infusions in partial responder CRPC patient (FG60163). (b) and (c) Similar cytokine profiles and Th₁ cytokine responses were seen in two minor responder CRPC patients (FG60202 and FG91760) during and after aATC infusions.

(a)

(b)

(c)