Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer

Table 1

Summary of prospective manuscripts studying relationship of acute and late GI toxicity after prostate RT.

Study name [citation]	Study design	Toxicity analysis time points		Toxicity grading system		Follow-up duration	Acute & late toxicity correlation
		Acute end	Late start	Acute	Chronic
Medical Research Council RT01 trial, Barnett et al. 2011 [12]	(i) Arm 1: 74 Gy/37 F () 3DCRT; (ii) Arm 2: 64 Gy/32 F () 3DCRT	6 W PTC	2 Y PTC	Acute RTOG	Late RTOG, LENT/SOMA, UCLA-PCI, RMH	Median not reported (2–5 Y)	Yes
Arcangeli et al. 2011 [13]	(i) Arm 1: 80 Gy in 40 F () 3DCRT; (ii) Arm 2: 62 Gy in 20 F () 3DCRT	1 M PTC	6 M PTC	Modified acute RTOG	Modified LENT/SOMA	(i) Arm 1 median 32 M (8–66 M); (ii) Arm 2 median 35 M (7–64 M)	Yes
Pinkawa et al. 2010 [14]	70.2 or 72 Gy in 1.8–2.0 Gy/F (), 3DCRT	6 M PTC	12 M PTC	Expanded Prostate Cancer Index Composite (EPIC)	Expanded Prostate Cancer Index Composite (EPIC)	Median 16 M (12–20 M)	Yes
Kertesz et al. 2009 [15]	(i) 60–72 Gy, 1.8–2 Gy/F, (), 3DCRT; (ii) Unreported number on ADT	TRT	Assume 90 D PTC	CTC v2	RTOG, LENT/SOMA	Median 50 M (9–59 M)	Yes
Guckenberger et al. 2010 [16]	(i) 76.23 Gy/33 F () IMRT; (ii) 73.91 Gy/32 F () post prostatectomy IMRT	6 W PTC	6 M PTC	CTCAE v3.0	CTCAE v3.0	Median 26 M	Yes
AIROPROS 0102, Fellin et al. 2009 [17]	70 Gy, 1.8–2 Gy/F (), 3DCRT	1 M PTC	6 M PTC	Custom fecal incontinence and bleeding questionnaire	Custom fecal incontinence and bleeding questionnaire	Median 36 M	Yes
Koper et al. 2004 [18]	(i) 66 Gy in 2 Gy/F () 3DCRT; (ii) 66 Gy in 2 Gy/F () Conventional; (iii) 15% got adjuvant ADT	Assume 90 D PTC	1 Y PTC	Acute RTOG, modified Tait, and Fransson questionnaire	Late RTOG, modified Tait, and Fransson questionnaire	Median not reported, 93% followed to 2 Y	Yes
Heemsbergen et al. 2006 [21]	(i) 68 Gy in 2 Gy/F () 3DCRT; (ii) 78 Gy in 2 Gy/F () 3DCRT	28 to 120 D PTC	120 D PTC	Acute RTOG, maximum score of acute mucous discharge	Late RTOG	Median 44 M	Yes
Trans-tasman radiation oncology group, O’Brien et al. 2002 [19]	52.5 Gy in 20 F () or 63–65 Gy in 2 Gy/F fractions (), conventional	Assume 90 D PTC	Assume 90 D PTC	Assume RTOG/EORTC	RTOG/EORTC	Median 63 M	Yes
Goineau et al. 2013 [20]	(i) 76 Gy in 38 F (), IMRT; (ii) ADT (6 M to 3 Y)	2 M PTC	6 M PTC	CTCAE V3,; QLQ-C30, and QLQ-PR25	CTCAE V3,; QLQ-C30, and QLQ-PR25	54 M	No

PTC = posttreatment completion, univariate (UV), multivariate (MV), androgen deprivation therapy (ADT), and TRT = throughout radiotherapy.
Acute RTOG = Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer acute morbidity rating scale.
Late RTOG = Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer late morbidity rating scale.
LENT = Late Effects Normal Tissue Task Force scale.
SOMA = Subjective, Objective, Management, and Analytic (SOMA) scales.
UCLA-PCI = University of California Loss Angeles Prostate Cancer Index.
RMH scale = Royal Marsden Hospital scale.
EPIC = Expanded Prostate Cancer Index Composite.
CTC v2 = Common Toxicity Criteria v2.0.
CTCAE V3 = Common Terminology Criteria for Adverse Events v3.0.
QLQ-C30 = EORTC QLQ-C30 quality of life questionnaire.
QLQ-PR25 = EORTC QLQ-PR25 quality of life questionnaire.
WHO = World Health Organization criteria.