Fortifying the Treatment of Prostate Cancer with Physical Activity

Figure 2

Metabolic manipulation of the AMPK overlaps with activation via exercise. Lightning bolts indicate pathways that affect radiosensitivity. AMPK, AMP-activated protein kinase; IGF-1, insulin growth factor-1; IRS, insulin receptor substrate; LKB1, liver kinase B1; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase. Image is used with permission from Champ et al., 2013 [33].