Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease

<table>Neuroprotection against 6-OHDA toxicity following delayed subchronic intranigral administration of 2<i>R</i>,4<i>R</i>-APDC (10 nmol in 4 <svg height="12.175" id="M100" style="vertical-align:-3.56265pt" version="1.1" viewbox="0 0 9.5625 12.175" width="9.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>L) translates into functional recovery of motor deficits. (a) Bar graph of mean percentage forelimb use asymmetry <svg height="9.5625" id="M101" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 10.1 9.5625" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> s.e.m in vehicle and 2<i>R</i>,4<i>R</i>-APDC (10 nmol)-treated animals, <svg height="17.825001" id="M102" style="vertical-align:-3.27605pt" version="1.1" viewbox="0 0 76.137497 17.825001" width="76.137497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, vehicle versus 2<i>R</i>,4<i>R</i>-APDC. (b) Bar graph of amphetamine-induced rotational behavior, expressed as net ipsilateral turns over 60 minutes <svg height="9.5625" id="M103" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 10.1 9.5625" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> s.e.m in vehicle and 2<i>R</i>,4<i>R</i>-APDC-treated animals, <svg height="17.825001" id="M104" style="vertical-align:-3.27605pt" version="1.1" viewbox="0 0 83.125 17.825001" width="83.125" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, vehicle versus 2<i>R</i>,4<i>R</i>-APDC.</table>

Parkinson’s Disease

fig2

Figure 2

Figure 2: Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease 

Figure 2 | Neuroprotection and Functional Recovery Associated with Decreased Microglial Activation Following Selective Activation of mGluR2/3 Receptors in a Rodent Model of Parkinson's Disease 