VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease
Figure 1
VMAT2-deficient animals display impaired stride length at older ages. (a) No deficits in forepaw stride length were apparent at 12 or 18 months of age in VMAT2-deficient mice. At 28 months of age, VMAT2-deficient mice display motor deficits as measured by inked paw stride length. Results represent average stride length (cm) ± SEM for 4–6 animals per genotype, **. (b) Representative forepaw stride lengths for VMAT2 WT and deficient mice at 12 and 28 months of age.
