VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease

Table 1

Summary of L-DOPA responsive Parkinsonian symptoms.

Behavior	L-DOPA responsive in VMAT2-Deficient?	L-DOPA responsive in humans?
Olfactory Discrimination	No	No
Sleep Latency	Yes	No
Anxiety	Suggested	Variable
Depression	Yes	Variable
Gastrointestinal Dysfunction	No	No
Locomotor Activity	Yes	Yes∗
Forepaw Stride Length	Yes	Yes∗

∗Falling, freezing of gait, and postural instability are all L-DOPA unresponsive.