Development of a Non-Motor Fluctuation Assessment Instrument for Parkinson Disease
Table 2
Ranking of non-motor fluctuations (NMFs) symptoms by study participants*.
Rank
Symptom
Frequency¶
Importance score*
Summary score†
1
Pain (OFF)
10
50
500
2
Confusion (OFF)
9
42
378
3
Poor concentration (OFF)
9
41
369
4
Frustration (OFF)
8
40
320
5
Urinary frequency (ON); urgency/incontinence (OFF)
7
33
231
6
Word-finding difficulty (OFF)
7
33
231
7
Word-finding difficulty (OFF)
7
25
175
8
Drooling (OFF)
6
23
138
9
Poor short-term memory (OFF)
5
25
125
10
Obsessive/compulsive behavior (OFF)
6
20
120
11
Poor judgment (OFF)
5
15
75
12
Depression (OFF)
5
14
70
13
Mood swings/emotional lability/irritability (OFF)
5
12
60
14
Insomnia (ON, OFF)
3
14
42
15
Agitation/irritability/impatience (OFF)
3
10
30
16
Lack of interest (OFF)
3
9
27
17
Decreased laughter (apathy?) (OFF)
2
12
24
18
Difficulty breathing (OFF)
2
11
22
19
Fatigue (OFF)
3
7
21
20
Hallucinations (OFF)
2
10
20
21
Increased perspiration/odor (ON)
2
7
14
22
Paranoia (OFF)
2
6
12
23
Double/blurry vision (OFF)
2
5
10
24
Decreased communication/social withdrawal (OFF)
1
7
7
25
Decreased reading comprehension (OFF)
1
6
6
26
Reduced coping skills (OFF)
1
6
6
27
Reduced sense of taste (OFF)
1
5
5
28
Tingling (OFF)
1
5
5
29
Constipation (ON)
1
5
5
30
Change in hearing (OFF)
1
3
3
31
Intermittently sleepy (OFF)
1
3
3
32
Numbness (OFF)‡
0
0
0
33
Restlessness (ON)
0
0
0
*Summation of individual scores. †Summary score: frequency X score. ‡Mentioned as symptom but not ranked in top 7. ¶Frequency: number of subjects ranking symptom. 19 participants asked to rank symptoms from 1–7 (least to most important). 133 total possible. 121/133—some subjects did not rank all 7.
