Review Article

Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation

Table 2

Experimental DBS with indications and target regions under study.

IndicationTarget regionReferences

Parkinson’s disease, progressive supranuclear palsyPedunculopontine (PPN) nucleus [144146, 148, 149]

Tremor types other than essential and Parkinsonian tremor (Holmes tremor, dystonic tremor, thalamic tremor, essential writer’s tremor, and neuropathic tremor)Ventrointermediate (VIM), ventral oralis (Vo) and anterior and posterior nucleus thalami, and subthalamic nucleus (STN) [156159]

Huntington’s diseaseGlobus pallidusinternus and externus (Gpi and Gpe) [160, 161]

Alzheimer’s diseaseFornix/hypothalamus[162]

Thalamic pain and poststroke fixed dystoniaPosterior limb of internal capsule [163, 164]

Central nociceptive pain syndromes (ischemia, hemorrhage, multiple sclerosis, spinal cord, and injury)Periaqueductal/periventricular gray matter (PAG/PVG)[165]

Peripheral neuropathic pain (postzoster neuralgia, radiogenic plexus lesion, phantom pain, postdissectomy syndrome, chronic radiculopathy, and carcinoma pain)Ventroposterolateral/ventroposteromedial (VPL/VPM) nucleus thalami, ventrocaudal (Vc) nucleus thalami, medial lemniscus, and PAG/PVG [165, 166]

EpilepsyAnterior and centromedian nucleus (AN and CMN) thalami, mammillary body (MB) hypothalamic and mamillothalamic tract, STN, hippocampus, caudate nucleus (CN), and cerebellum [167, 168]

Obsessive-compulsive disorderAnterior limb of internal capsule (ALIC), STN, ventral caudate, inferior thalamic peduncle, nucleus accumbens (NAc), and ventral capsule/ventral striatum (VC/VS) [2529, 169171]

DepressionSubcallosal cingulated gyrus, inferior thalamic peduncle, NAc, VC/VS [29, 172174]

Gilles de la Tourette syndromeCentromedian-parafascicular (Cm-Pf) and Vo complex thalami, Gpi, and NAc [17, 29]

Minimally conscious stateCentral thalamus [175]