Clinical Study
Nonmotor Symptoms in Patients with PARK2 Mutations
Table 3
Olfactory function by Sniffin' sticks and PSG study in patients with PARK2 mutation, controls, and Parkinson's disease.
| | Case | 1 | 2 | 3 | 4 | 5 | 6 | PARK2 total () | Control () | Parkinson's disease () |
| | Age | 71 | 55 | 46 | 41 | 38 | 36 | | | | | Sniffin’ sticks Test | | | | | | | | | | | Threshold test | 4.5 | 6.3 | 6.3 | 5.8 | 5.0 | 9.0 | |
*
|
**
| | Discrimination test | 8.0 | 9.0 | 12.0 | 14.0 | 9.0 | 8.0 | | | | | Identification test | 1.0 | 13.0 | 10.0 | 14.0 | 13.0 | 10.0 | | | |
| | PSG findings | | | | | | | | | | | Apnea index (times/H) | 10.1 | 22.5 | 1.2 | 0.4 | 1.0 | 2.1 | | | | | Hypopnea index (times/H) | 2.2 | 14.0 | 4.7 | 0.3 | 1.9 | 9.4 | | | | | Apnea Hypopnea index (times/H) | 12.3 | 36.5 | 5.9 | 0.8 | 3.0 | 11.4 | | | | | Arousal index (times/H) | 16.0 | 39.8 | 37.7 | 13.4 | 14.3 | 11.1 | | | | | Respiratory arousal index (times/H) | 5.5 | 27.3 | 4.6 | 0.2 | 1.6 | 3.3 | | | | | PLM index (times/H) | 7.8 | 0.0 | 7.7 | 0.0 | 29.5 | 0.0 | | | | | PLM arousal index (times/H) | 0.0 | 0.0 | 5.3 | 0.0 | 2.8 | 0.0 | | | | | REM sleep twitching on TA muscle | − | + | − | + | − | − | | | |
|
|
H/M: theheart to mediastinum uptake ratio, NE: not examined.
PLM: periodic limb movements, TA: tibialis anterior.
*
t-test: compared with PARK2 patients .
**
t-test: compared with PARK2 patients and control .
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