Representative still frames of a Mn-inhaled mouse (a–d) and Mn-inhaled mouse + L-DOPA treatment (e–h). In frames (a)–(d), the mouse showed impairments using extreme postural adjustments advancing the limb diagonally through the slot making many short attempts rather than aligning the limb with the midline of the body. The digits are concurrently adducted. The paw comes in from the side or slaps laterally, and digits do not contact the food pellet. The mouse is dragging its limb through the slot and dropping the pellet to the floor cage chasing the food with the tongue rather than fully pronating the paw and supinating it to present the food to the mouth. In contrast, in frames (e)–(h), the effect of L-DOPA treatment is evident, and the mouse adjusts its posture, directs the arm to the food pellet, and closes its digits to obtain it correctly.
