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Parkinson’s Disease
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Special Issues
Parkinson’s Disease
/
2011
/
Article
/
Tab 3
/
Review Article
Toxin-Induced and Genetic Animal Models of Parkinson's Disease
Table 3
Autosomal-recessive PD models and other causative genes of PD.
Gene
Animal
Manipulation
DA neuron loss
LB-like inclusion
DA-responsive motor deficits
References
Parkin
(
PARK2
)
Nematode
Knockout
No
No
No
[
124
]
Fly
Knockout
Yes
No
Yes
[
125
,
126
]
Transgenic
Yes
No
Yes
[
131
,
132
]
Mouse
Knockout
No
No
ND
[
127
–
130
]
Transgenic
Yes
Yes
ND
[
133
]
PINK1
(
PARK6
)
Fly
Knockout
Yes
No
Yes
[
135
,
136
]
Mouse
Knockout
No
No
ND
[
137
–
139
]
DJ-1
(
PARK7
)
Fly
Knockout
Yes
No
Yes
[
144
–
148
]
Mouse
Knockout
No
No
ND
[
149
–
151
]
HtrA2/Omi
(
PARK13
)
Fly
Knockout
No
No
No
[
153
]
Mouse
Knockout
No
No
ND
[
154
,
155
]
Nurr1
(
NR4A2
)
Mouse
Knockout
Yes
No
ND
[
158
–
160
]
DA, dopamine; LB, Lewy body; ND, not determined.
1
LB-like inclusions by definition contain filamentous
α
-synuclein.
2
ND could include some degree of behavioral impairment in spontaneous and locomotor activity and in response to sensory stimulation.