Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease
Table 4
Total Motor UPDRS ON and OFF medication by PD subtype ().
PD subtype
Tremor-dominant () mean (SD)
Akinetic rigid () mean (SD)
Mixed () mean (SD)
ANOVA value
Total Motor UPDRS ON medication
12.1 (7.8)a
18.9 (11.4)b
13.2 (5.1)a
0.001
Total fMotor UPDRS OFF medication
19.3 (9.9)a
26.9 (12.1)b
20.9 (5.7)a
0.001
Difference between ON and OFF
7.2 (5.1)a
8.0 (5.4)a
7.7 (1.9)a
0.73
Levodopa dosage per day (mg)
551.6 (306.2)a ()
613.6 (285.4)a ()
569.6 (357.6)a ()
0.54
Hoehn and Yahr–OFF medication
(%)
(%)
(%)
Chi-square -value
1
5 (15.2)
5 (3.5)
0 (0.0)
0.003
1.5
5 (15.2)
4 (2.8)
3 (16.7)
2
14 (42.4)
42 (29.6)
8 (44.4)
2.5
5 (15.2)
46 (32.4)
3 (16.7)
3
3 (9.1)
27 (19.0)
4 (22.2)
4
1 (3.0)
11 (7.8)
0 (0.0)
5
0 (0.0)
7 (4.9)
0 (0.0)
UPDRS = Unified Parkinson’s Disease Rating Scale.
*One subject excluded, because they were on MAO-B inhibitors alone.
a, bMeans within a row with different letters differ significantly (; pairwise t-test).