Genetic Rat Models of Parkinson's Disease

Table 1

Summary of studies using genetic rat models of PD. Note that % cell loss SNpc is percentage of cell loss in the substantia nigra, pars compacta, relative to number of cells in the intact, untreated controls; “n.a.” indicates data for percentage loss of SNpc cells was not available; plus sign (+) indicates significant differences and “n.s.” indicates non-significant differences between genetically altered rats and wild-type controls on measures of protein aggregation or behavioral deficits (i.e., stimulant-induced rotational activity, paw placement in cylinder task, and/or spontaneous motor activity in open-field).

Gene	Method	Percentage of cell loss SNpc	Protein aggregation	Behavior deficit	Author year
hα-syn, α-syn A53T	rAAV	30%–80%	+	+ (in 25% of animals)	Kirik et al. 2002 [12]
hα-syn A30P	rAAV	53%	+	n.s.	Klein et al. 2002 [13]
hα-syn A30P	HIV-1 Lentivirus	33%	+	None performed	Lo Bianco et al. 2002 [14]
hα-syn A53T	HIV-1 Lentivirus	24%	+	None performed	Lo Bianco et al. 2002 [14]
hα-syn	rAAV	50%	+	n.s.	Yamada et al. 2004 [15]
hα-syn	rAAV2/5	40–60%	+	None performed	Gorbatyuk etal. 2008 [16]
hα-syn S129A	rAAV2/5	66–70%	+	None performed	Gorbatyuk etal. 2008 [16]
hα-syn S129D	rAAV2/5	n.a.	+	None Performed	Gorbatyuk et al. 2008 [16]
hα-syn	rAAV2/6	11–22%	+	None Performed	da Silveira et al. 2009 [17]
hα-syn A30P	rAAV2/6	11–22%	+	None Performed	da Silveira et al. 2009 [17]
hα-syn WT S129A	rAAV2/6	over 70%	+	None Performed	da Silveira et al. 2009 [17]
hα-syn WT S129D	rAAV2/6	n.a.	+	None Performed	da Silveira et al. 2009 [17]
hα-syn A30P S129A	rAAV2/6	over 70%	+	None Performed	da Silveira et al. 2009 [17]
hα-syn A30P S129D	rAAV2/6	n.s.	+	None Performed	da Silveira et al. 2009 [17]
hα-syn A30P	TAT	21.3–31.3%	n.s.	+	Recchia et al. 2008 [18]
hα-syn A30P A53T	Microinjection	n.a.	n.s.	+	Lelan et al. 2011 [19]
LRRK2 G2019S	Rad	21.4%	n.s.	None Performed	Dusonchet et al. 2011 [20]
LRRK2 G2019S	TRE-tTA	0%	n.s.	+	Zhou et al. 2011 [21]