Mitochondrial Dynamics and Mitophagy in the 6-Hydroxydopamine Preclinical Model of Parkinson's Disease

Figure 1

Mitochondrial fission and autophagy events are activated after 6-OHDA addition. Drp1 and Bax translocate from the cytosol to mitochondria. Drp1 has been proposed to encircle mitochondria to mediate constriction and this is followed by scission, which results in the formation of two separate mitochondria. Mitochondrial fission may play a role in the removal of dysfunctional mitochondria with reduced mitochondrial membrane potential, through an autophagy-lysosomal pathway named “mitophagy.”