Neuropsychiatric Symptoms in Parkinson's Disease with Mild Cognitive Impairment and Dementia

Table 5

Proportion of Neuropsychiatric Inventory (NPI) domains endorsed by the three PD groups.

	PD		PD
	No cognitive		Mild cognitive		PD dementia
	impairment		impairment		(PDD; 𝑛=25)		Statistic (𝜒^2; 𝑃-value)
	(PD-NC; 𝑛=54)		(PD-MCI; 𝑛=48)
	%
NPI sub-scores	Any*	≥4**	Any	≥4	Any	≥4	Any	≥4
Delusions	3.7	3.7	4	2	28.0	12.0	28.40; <0.001^b, c	10.08; 0.07
Hallucinations	11.1	1.9	14.0	4.0	32.0	12.0	37.21; <0.001^c	18.2; 0.003^c
Agitation/aggression	7.4	3.7	6.0	2	36.0	8.0	32.47; <0.001^b, c	6.38; 0.23
Dysphoria/depression	33.3	9.3	36.0	6.0	56.0	20.0	48.92; <0.001^b, c	15.07; 0.01^a
Anxiety	42.6	11.1	36.0	12.0	48.0	12.0	43.62; <0.001^b, c	9.19; 0.10
Euphoria	7.4	3.7	2.0	2.0	4.0	0.0	8.84;0.12	8.53; 0.13
Apathy	16.7	11.1	48	38	52.0	36.0	50.99; <0.001^a, c	37.43; <001^a, c
Disinhibition	3.7	1.9	2	2	12.0	0.0	9.10;0.11	4.79; 0.44
Irritability/lability	22.2	9.3	14.0	4.0	52.0	16.0	44.65; < 0.001^b, c	11.75; 0.04^c
Aberrant motor behaviours	5.6	3.7	0	0	24.0	16.0	23.18; <0.001^b, c	15.49; 0.01^c
Sleep	55.6	37.0	58.0	42.0	40.0	32.0	44.04; <0.001	52.93; <0.001^b
Appetite	7.4	1.9	2.0	0	20.0	16.0	15.85; 0.003^c	12.9; 0.01^c

*Indicates any Neuropsychiatric Inventory (NPI) symptoms >0; **indicates NPI score of ≥4.
Post  hoc bonferroni for two group comparison, 𝑃<0.05: ^aPD-NC versus PD-MCI; ^bPD-MCI versus PDD; ^cPD-NC versus PDD.