Parkinson’s Disease / 2012 / Article / Tab 2 / Review Article
Imbalanced Dopaminergic Transmission Mediated by Serotonergic Neurons in L-DOPA-Induced Dyskinesia Table 2 Changes in biochemical, morphological, and molecular 5-HT indexes in dyskinetic (LID) versus nondyskinetic (LND) animals: correlation with dyskinesias (R).
Animal model L-DOPA treatment Biochemical 5-HT indexes LID versus LND (R) Reference 6-OHDA rats 6 mg/kg/d ip 14 d tiss 5-HT: STR and CXLID > LND R = 0.73 in CX [84 ] 6-OHDA rats 12 mg/kg/d sc 5 d tiss 5-HT (5,7-DHT): STRR = 0.713 [85 ] 6-OHDA rats 6 mg/kg/d sc 14 d ext and tiss 5-HT and 5-HIAA: STR and SNrLID > LND in STR [48 ] 6-OHDA rats 6 mg/kg/d ip 21 d tiss 5-HT: STRLID > LND R = −0.655 [72 ] Animal model L-DOPA treatment Morphological 5-HT indexes LID versus LND (R) Reference 6-OHDA rats 5 mg/kg/d ip 14 d SERT immunoreactivity: STR LID > LND [73 ] 6-OHDA rats 6 mg/kg/d ip 21 d 5-HT immunoreactivity and AADC levels: STR LID > LND [74 ] 6-OHDA rats 6 and 50 mg/kg/d ip 14–21 d SERT-binding density: STR and CX LID > LND, R = 0.796 in STR [55 ] MPTP monkeys Modopar (4 : 1) 15–20 mg/kg po 6–8 m SERT-binding density: PUT and GP LID > LND in PUT [55 ] Animal model L-DOPA treatment Molecular 5-HT indexes LID versus LND (R) Reference MPTP monkeys Prolopa 100/25 mg/kg po 1 m 5-HT2A R-binding: STR and PFC LID > LND in DM Caud and anterior cingulate gyrus [78 ]
6-OHDA: 6-hydroxydopamine; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; ip: intraperitoneal; sc: subcutaneous; po: oral; d: day; m: month; tiss : tissue; ext : extracellular; 5-HT: serotonin; 5-HIAA: 5-hydroxyindolacetic acid; 5,7-DHT: 5,7-dihydroxytryptamine; AADC: amino acid decarboxylase; SERT: serotonergic transporter; 5-HT2A R: serotonin 2A receptor; STR: striatum; CX: cortex; SNr: substantia nigra pars reticulata; PUT: putamen; PFC: prefrontal cortex; GP: globus pallidus; DM Caud: dorsomedial caudate nucleus; LID: L-DOPA-treated dyskinetic animals; LND: L-DOPA-treated nondyskinetic animals; R: correlation.