Review Article
The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease
Table 1
Functions of known and predicted mitochondrial DUBs.
| DUB | Function(s) | Reference(s) |
| Ataxin-3 | Protein quality control; mitophagy; neuroprotective properties | [68, 70–72] | USP9x | Cell differentiation and survival; synaptic function | [63, 65] | USP30 | Mitochondrial membrane dynamics | [59] | USP36 | Nucleolar structure and function; oxidative stress | [61, 62] |
| JOSD1 | Unknown | | USP2 | NF-kappaB signalling; AIF-mediated cell death | [73, 74] | USP16 | Histone deubiquitination; gene expression | [75] | USP29 | Oxidative stress | [76] | USP44 | Cell cycle regulation | [50] | USP50 | Cell cycle regulation | [77] |
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