Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis
Figure 1
GFAP immunoreactivity in the human frontal cortex. (a–h) examples of GFAP immunoreactivity in grey (a–d) and white matter (e–h) of a 77-year-old female control (C) donor (NBB 2001-104; a, e), a 77-year-old male Parkinson’s disease (PD) patient (NBB 2005-069; b, f), a 71-year-old male Parkinson’s disease with dementia (PDD) patient (NBB 2004-045; c, g), and 76-year-old female dementia with Lewy bodies (DLB) patient (2001-025; d, h). (i-j) Boxplot of the quantification of GFAP staining in grey (i) and white matter (j) of 8 C, 6 PD, 11 PDD, and 9 DLB cases. (k) correlation of GFAP expression in the grey matter with age of the 34 donors. GM: grey matter; WM: white matter; inserts show higher magnification images of the same patients. Scale bars represent 50 μm for the lower magnification and 20 μm for the higher magnification images.
