Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis
Figure 3
Astrocytic protein levels in ventricular cerebrospinal fluid (CSF). (a) example of a Western blot for GFAP (top row) and vimentin (bottom row) on CSF of different donors (from left to right: NBB 2006-030, 2007-007, 2007-008, 2007-019, 2005-017, 2005-050, 2005-055, 2005-069, and 2005-077). (b) correlation of the GFAP and vimentin protein levels (in arbitrary units) in CSF of 36 donors. (c) Boxplot of GFAP protein levels in CSF of 8 control (c), 8 Parkinson’s disease (PD), 11 PD with dementia (PDD), and 9 dementia with Lewy bodies (DLB) cases. (d) Boxplot of vimentin protein levels in CSF of 8 C, 8 PD, 11 PDD, and 9 DLB cases.
