Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis
Figure 4
α-synuclein pathology in the human frontal cortex. (a–c) Lewy bodies (arrows) and Lewy neurites (arrowheads) in the grey matter of a Parkinson’s disease (PD; NBB 1999-038), Parkinson’s disease with dementia (PDD; NBB 2004-045), and dementia with Lewy bodies (DLB; NBB 1997-092) case. (d) a Lewy body (arrow) in the white matter (WM) of the frontal cortex of case NBB 2004-045. (e) Boxplot of the quantification of Lewy body number in the frontal cortex of 8 control, 6 PD, 11 PDD, and 9 DLB cases. (f) Lewy body numbers per ApoE genotype. Scale bars represent 100 μm.
