Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis

Table 2

Clinicopathological data of individual donors.

NBB number	Diagnosis	IHC	CSF	Sex	Age (yrs)	Age of onset (yrs)	Disease duration (yrs)	PMD (hr: min)	pH CSF	Brain weight (gr.)	ApoE	GDS	Braak stage (Tau/amyloid)	Braak stage PD	Cause of death
1988-109	DLB	+	−	M	78	?	?	03:15	6.77	1240	33		1 B		Angina pectoris
1992-055	DLB	−	+	M	72	64	8	04:15	6.77	1423	32	7	1		Aspiration pneumonia
1995-109	PD	+	+	M	70	66	4	05:35	6.6	1602	32		1		Pneumonitis
1997-064	PD	−	+	M	65	39	26	06:00	6.35	1319	33		1		Sepsis after urinary tract infection
1997-092	DLB	+	+	F	79	77	2	03:20	6.4	1011	43	7	1	5	Influenza
1997-126	PD	−	+	F	83	78	5	04:40	6.16	1084	33		1	5	Natural death
1997-138	DLB	+	+	M	74	70	4	04:15	6.12	1093	43	7	1	5	Cachexia
1998-043	PD	+	+	F	81	64	17	04:10	6.86	1330	32		1		Pneumonia
1998-088	PDD	+	+	M	76	66	10	05:15	6.64	1283	32	4	1	5	Pneumonia
1999-038	PDD	+	+	F	86	71	15	06:00	6.34	1103	33		1 A	5	Dehydration
2000-015	C	+	+	M	78	—	—	05:35	6.63	1467	43		1 O		Thrombus leg/respiratory insufficiency
2000-115	PDD	+	+	M	70	53	17	09:05	6.33	1258	33	3	1 O		Pneumonia/septic shock
2001-025	DLB	+	+	F	76	66	10	04:05	6.52	1145	44	7	1 B		Dehydration
2001-026	DLB	+	+	F	72	65	7	07:25	7.64	1211	33	7	1 A		Dehydration
2001-037	DLB	+	+	M	80	78	2	06:40	6.47	1426	33	7	1 B		General deterioration
2001-045	C	+	+	M	83	—	—	04:35	6.49	1422	33		1 B	0	Heart attack
2001-046	C	+	+	M	88	—	—	07:25	6.5	1228	33		1 C	0	Metastasized prostate carcinoma (patient requested euthanasia*)
2001-104	C	+	−	F	77	—	—	05:30	6.74	1343	43		1 B		Lung metastases from Mammacarcinoma
2001-122	PD	+	+	M	86	60	26	05:35	6.19	1244	33		1 O	4	Aspiration pneumonia
2002-017	DLB	+	+	M	72	60	12	06:50	6.32	1270	43	6	1 A		Dehydration
2002-024	C	−	+	F	75	—	—	05:30	7.2	1197	42		1 C	0	Heart attack
2002-048	DLB	+	+	M	70	63	7	04:25	6.56	1211	43	6	1 A		Cachexia
2002-087	C	+	+	M	71	—	—	07:40	6.2	1190	33		1 O		Sepsis
2002-105	PD	+	+	M	83	77	6	06:20	6.71	1475	33		1 A		Cerebrovascular accident
2003-059	PDD	+	+	F	75	71	4	06:10	6.38	1258	43		1 A		Dementia/dehydration/fever
2003-078	PDD	+	+	F	61	53	8	04:30	6.3	1134	43		1 B		Abdominal problems
2004-033	PDD	+	+	M	73	69	4	05:35	6.8	1322	42		1 A	5	Unknown
2004-045	PDD	+	+	M	71	59	12	06:58	6.55	1358	43	6	1 C	6	Pneumonia
2004-057	C	+	−	F	81	—	—	06:40	7.16	1164	33		1 B	0	Metastasized cholangiocarcinoma (patient requested euthanasia**)
2004-059	PD	+	+	M	74	53	21	02:50	6.55	1259	33		1 O	5	Dehydration/uremic coma
2004-081	PDD	+	+	M	88	78	10	05:50	6.66	1205	32	2	1 C	6	Unknown
2005-017	C	+	+	M	87	—	—	10:20	6.32	1356	33		1 A	2	Pneumonia/heart failure
2005-050	PD	+	+	M	84	82	2	06:05	6.42	1243	43		1 C	5	Heart attack
2005-055	C	+	+	M	84	—	—	07:05	5.9	1385	33		1 O		Exacerbation of COPD
2005-069	PD	+	+	M	77	64	13	08:05	6.45	1380	32		1 O	5	Pneumonia leading to septic shock
2005-077	PDD	+	+	M	83	81	2	05:15	6.66	1276	33	6	1 B	6	Pneumonia
2006-030	PDD	+	+	F	80	68	12	05:15	6.31	1288	43	7	1 C		Dehydration with general deterioration
2007-007	C	+	+	M	84	—	—	05:35	6.98	1457	33		1 A	0	Heart failure
2007-008	PDD	+	+	M	80	74	6	07:05	6.34	1612	43	5	1 B	6	Unknown
2007-019	DLB	+	+	M	86	82	4	06:45	6.2	1180	43	7	1 B		Dehydration/cachexia after TIA

NBB: Netherlands Brain Bank; C: nondemented control; PD; Parkinson’s disease; PDD: PD with dementia; DLB: dementia with Lewy bodies; IHC: immunohistochemistry investigated; CSF: cerebrospinal fluid investigated; M: male; F: female; ApoE: ApoE genotype; GDS: global deterioration scale [16]; Braak stage is a scale for Alzheimer’s pathology, scoring tau [28], and amyloid [29] pathology; PMD: postmortem delay; pH CSF indicates the agonal state of the donor [30]; COPD: chronic obstructive pulmonary disease; TIA: transient ischemic attack; *euthanasia is legal according to Dutch law, the patient died of a combination of fentanyl, midazolam, thiopental, and pancuronium; **patient died of a combination of thiopental and pancuronium.