Review Article

Parkinson’s Disease and Autophagy

Figure 2

ROS/RNS production as a result of defective mitochondria respiratory activity can be induced by a number of factors like protein aggregates. Reactive species can also be generated by other cellular oxidases. These ROS/RNS species can modify several proteins which can stimulate and/or inhibit autophagy. In addition, reactive species produced or not in the mitochondria can target this organelle and induce further damage to it.
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