Research Article
Adenosine Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease
Table 1
Mean startle magnitude ± SEM in rat prepulse inhibition (* versus vehicle).
| Drug | Dose (mg/kg) | Startle |
| SCH 412348 | Veh. | 193.3 ± 46.6 | 0.3 | 223.4 ± 59.5 | 1.0 | 166.0 ± 20.2 | 3.0 | 213.0 ± 46.3 |
| Istradefylline | Veh. | 196.5 ± 50.8 | 0.1 | 163.7 ± 26.7 | 0.3 | 161.5 ± 23.3 | 1.0 | 175.0 ± 36.9 |
| Pramipexole | Veh. | 229.5 ± 32.1 | 0.3 | 121.4 ± 14.4* | 1.0 | 134.7 ± 32.0* | 3.0 | 101.6 ± 14.2* |
| Pergolide | Veh. | 139.9 ± 20.7 | 0.3 | 104.9 ± 27.1 | 1.0 | 111.0 ± 19.1 | 3.0 | 84.0 ± 11.1 |
| Ropinirole | Veh. | 250.2 ± 49.7 | 1.0 | 218.8 ± 33.7 | 3.0 | 73.0 ± 17.6* | 10.0 | 166.6 ± 26.7 | 30.0 | 111.4 ± 22.1* |
| L-dopa | Veh. | 228.7 ± 124.7 | 10 | 183.5 ± 31.0 | 30 | 269.8 ± 63.7 | 100 | 239.0 ± 45.1 | 300 | 197.2 ± 49.8 |
| Apomorphine | Veh. | 303.2 ± 46.3 | 0.3 | 323.5 ± 44.3 | 0.5 | 456.3 ± 140.0 | 0.65 | 468.1 ± 76.2 | 0.8 | 355.2 ± 79.6 |
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