Adenosine A_𝟐A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease

Table 1

Mean startle magnitude ± SEM in rat prepulse inhibition (*𝑃<0.05 versus vehicle).

Drug	Dose (mg/kg)	Startle
SCH 412348	Veh.	193.3 ± 46.6
	0.3	223.4 ± 59.5
	1.0	166.0 ± 20.2
	3.0	213.0 ± 46.3
Istradefylline	Veh.	196.5 ± 50.8
	0.1	163.7 ± 26.7
	0.3	161.5 ± 23.3
	1.0	175.0 ± 36.9
Pramipexole	Veh.	229.5 ± 32.1
	0.3	121.4 ± 14.4*
	1.0	134.7 ± 32.0*
	3.0	101.6 ± 14.2*
Pergolide	Veh.	139.9 ± 20.7
	0.3	104.9 ± 27.1
	1.0	111.0 ± 19.1
	3.0	84.0 ± 11.1
Ropinirole	Veh.	250.2 ± 49.7
	1.0	218.8 ± 33.7
	3.0	73.0 ± 17.6*
	10.0	166.6 ± 26.7
	30.0	111.4 ± 22.1*
L-dopa	Veh.	228.7 ± 124.7
	10	183.5 ± 31.0
	30	269.8 ± 63.7
	100	239.0 ± 45.1
	300	197.2 ± 49.8
Apomorphine	Veh.	303.2 ± 46.3
	0.3	323.5 ± 44.3
	0.5	456.3 ± 140.0
	0.65	468.1 ± 76.2
	0.8	355.2 ± 79.6