Adenosine A_𝟐A Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease

Table 2

Mean startle magnitude ± SEM in mouse prepulse inhibition (*𝑃<0.05 versus vehicle).

Drug	Dose (mg/kg)	Startle
SCH 412348	Veh.	129.0 ± 17.8
	0.3	144.6 ± 17.8
	1.0	140.5 ± 20.7
	3.0	142.6 ± 12.9
Istradefylline	Veh.	125.9 ± 22.3
	0.1	104.9 ± 17.3
	0.3	110.9 ± 19.0
	1.0	75.9 ± 10.7
Pramipexole	Veh.	95.6 ± 8.7
	0.3	103.1 ± 13.2
	1.0	76.3 ± 8.5
	3.0	69.5 ± 10.5
Pergolide	Veh.	135.2 ± 23.5
	0.1	149.9 ± 12.3
	0.3	116.9 ± 17.6
	1.0	100.5 ± 15.1
	3.0	62.7 ± 10.9*
Ropinirole	Veh.	135.9 ± 19.7
	3.0	134.1 ± 15.2
	10.0	143.3 ± 15.6
	30.0	140.6 ± 18.0
L-dopa	Veh.	130.5 ± 20.9
	10.0	135.0 ± 16.4
	30.0	96.8 ± 14.4
	100.0	69.0 ± 5.8*
	300.0	50.7 ± 9.6*
Apomorphine	Veh.	149.9 ± 26.4
	0.3	93.1 ± 15.9
	1.0	90.6 ± 15.2
	3.0	94.7 ± 13.5