- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2012 (2012), Article ID 614212, 8 pages
Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
1Department of Neurology, Boston University School of Medicine, Boston, MA 02119, USA
2The Graduate Program in Bioinformatics, Boston University, Boston, MA 02215, USA
3Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
4Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Received 4 November 2011; Accepted 19 December 2011
Academic Editor: Kathleen A. Maguire-Zeiss
Copyright © 2012 Alexandra Dumitriu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. H. Polymeropoulos, C. Lavedan, E. Leroy et al., “Mutation in the α-synuclein gene identified in families with Parkinson's disease,” Science, vol. 276, no. 5321, pp. 2045–2047, 1997.
- R. Krüger, W. Kuhn, T. Müller et al., “Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease,” Nature Genetics, vol. 18, no. 2, pp. 106–108, 1998.
- J. J. Zarranz, J. Alegre, J. C. Gómez-Esteban et al., “The new mutation, E46K, of α-synuclein causes Parkinson and lewy body dementia,” Annals of Neurology, vol. 55, no. 2, pp. 164–173, 2004.
- A. B. Singleton, M. Farrer, J. Johnson et al., “α-synuclein locus triplication causes Parkinson's disease,” Science, vol. 302, no. 5646, p. 841, 2003.
- M. C. Chartier-Harlin, J. Kachergus, C. Roumier et al., “α-synuclein locus duplication as a cause of familial Parkinson's disease,” The Lancet, vol. 364, no. 9440, pp. 1167–1169, 2004.
- P. Ibáñez, A. M. Bonnet, B. Débarges et al., “Causal relation between α-synuclein gene duplication and familial Parkinson's disease,” The Lancet, vol. 364, no. 9440, pp. 1169–1171, 2004.
- M. Neystat, T. Lynch, S. Przedborski, N. Kholodilov, M. Rzhetskaya, and R. E. Burke, “α-synuclein expression in substantia nigra and cortex in Parkinson's disease,” Movement Disorders, vol. 14, no. 3, pp. 417–422, 1999.
- S. Kim, J.H. Seo, and Y.H. Suh, “Alpha-synuclein, Parkinson's disease, and Alzheimer's disease,” Parkinsonism & Related Disorders, vol. 10, supplement 1, pp. S9–S13, 2004.
- A. E. Kingsbury, S. E. Daniel, H. Sangha, S. Eisen, A. J. Lees, and O. J.F. Foster, “Alteration in α-synuclein mRNA expression in Parkinson's disease,” Movement Disorders, vol. 19, no. 2, pp. 162–170, 2004.
- E. K. Tan, V. R. Chandran, S. Fook-Chong et al., “Alpha-synuclein mRNA expression in sporadic Parkinson's disease,” Movement Disorders, vol. 20, no. 5, pp. 620–623, 2005.
- O. Chiba-Falek, G. J. Lopez, and R. L. Nussbaum, “Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients,” Movement Disorders, vol. 21, no. 10, pp. 1703–1708, 2006.
- M. Westerlund, A. C. Belin, A. Anvret et al., “Cerebellar α-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material,” FASEB Journal, vol. 22, no. 10, pp. 3509–3514, 2008.
- J. Fuchs, A. Tichopad, Y. Golub et al., “Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain,” FASEB Journal, vol. 22, no. 5, pp. 1327–1334, 2008.
- K. Beyer, L. Ispierto, P. Latorre, E. Tolosa, and A. Ariza, “Alpha- and beta-synuclein expression in Parkinson disease with and without dementia,” Journal of the Neurological Sciences, vol. 310, no. 1-2, pp. 112–117, 2011.
- M. Farrer, D. M. Maraganore, P. Lockhart et al., “α-synuclein gene haplotypes are associated with Parkinson's disease,” Human Molecular Genetics, vol. 10, no. 17, pp. 1847–1851, 2001.
- Y. Izumi, H. Morino, M. Oda et al., “Genetic studies in Parkinson's disease with an α-synuclein/NACP gene polymorphism in Japan,” Neuroscience Letters, vol. 300, no. 2, pp. 125–127, 2001.
- C. Holzmann, R. Krüger, A. M. M. Vieira Saecker et al., “Polymorphisms of the α-synuclein promoter: expression analyses and association studies in Parkinson's disease,” Journal of Neural Transmission, vol. 110, no. 1, pp. 67–76, 2003.
- J. C. Mueller, J. Fuchs, A. Hofer et al., “Multiple regions of α-synuclein are associated with Parkinson's disease,” Annals of Neurology, vol. 57, no. 4, pp. 535–541, 2005.
- D. M. Maraganore, M. De Andrade, A. Elbaz et al., “Collaborative analysis of α-synuclein gene promoter variability and Parkinson disease,” Journal of the American Medical Association, vol. 296, no. 6, pp. 661–670, 2006.
- G. H. Hadjigeorgiou, G. Xiromerisiou, V. Gourbali et al., “Association of α-synuclein Rep1 polymorphism and Parkinson's disease: influence of Rep1 on age at onset,” Movement Disorders, vol. 21, no. 4, pp. 534–539, 2006.
- I. Mizuta, W. Satake, Y. Nakabayashi et al., “Multiple candidate gene analysis identifies α-synuclein as a susceptibility gene for sporadic Parkinson's disease,” Human Molecular Genetics, vol. 15, no. 7, pp. 1151–1158, 2006.
- P. Pals, S. Lincoln, J. Manning et al., “α-Synuclein promoter confers susceptibility to Parkinson's disease,” Annals of Neurology, vol. 56, no. 4, pp. 591–595, 2004.
- S. Sotiriou, G. Gibney, A. D. Baxevanis, and R. L. Nussbaum, “A single nucleotide polymorphism in the 3′UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease,” Neuroscience Letters, vol. 461, no. 2, pp. 196–201, 2009.
- C. Linnertz, L. Saucier, D. Ge et al., “Genetic regulation of α-synuclein mRNA expression in various human brain tissues,” PLoS ONE, vol. 4, no. 10, Article ID e7480, 2009.
- J. J. McCarthy, C. Linnertz, L. Saucier et al., “The effect of SNCA region on the levels of SNCA-112 splicing variant,” Neurogenetics, vol. 12, no. 1, pp. 59–64, 2011.
- P. J. Harrison, P. R. Heath, S. L. Eastwood, P. W. J. Burnet, B. McDonald, and R. C. A. Pearson, “The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins,” Neuroscience Letters, vol. 200, no. 3, pp. 151–154, 1995.
- K. A. Jellinger, K. Seppi, G. K. Wenning, and W. Poewe, “Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease,” Journal of Neural Transmission, vol. 109, no. 3, pp. 329–339, 2002.
- T. G. Beach, C. H. Adler, L. F. Lue et al., “Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction,” Acta Neuropathologica, vol. 117, no. 6, pp. 613–634, 2009.
- L. B. Moran, D. C. Duke, M. Deprez, D. T. Dexter, R. K. B. Pearce, and M. B. Graeber, “Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease,” Neurogenetics, vol. 7, no. 1, pp. 1–11, 2006.
- L. B. Moran, L. Hickey, G. J. Michael et al., “Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies,” Acta Neuropathologica, vol. 115, no. 4, pp. 471–478, 2008.
- I. Cantuti-Castelvetri, C. Keller-McGandy, B. Bouzou et al., “Effects of gender on nigral gene expression and parkinson disease,” Neurobiology of Disease, vol. 26, no. 3, pp. 606–614, 2007.
- N. Pankratz, J. B. Wilk, J. C. Latourelle et al., “Genomewide association study for susceptibility genes contributing to familial Parkinson disease,” Human Genetics, vol. 124, no. 6, pp. 593–605, 2009.
- J. C. Latourelle, N. Pankratz, A. Dumitriu et al., “Genomewide association study for onset age in Parkinson disease,” BMC Medical Genetics, vol. 10, article 1471, p. 98, 2009.
- M. G. Spillantini, M. L. Schmidt, V. M. Y. Lee, J. Q. Trojanowski, R. Jakes, and M. Goedert, “α-synuclein in Lewy bodies,” Nature, vol. 388, no. 6645, pp. 839–840, 1997.
- P. Preece and N. J. Cairns, “Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance,” Molecular Brain Research, vol. 118, no. 1-2, pp. 60–71, 2003.
- A. C. Birdsill, D. G. Walker, L. Lue, L. I. Sue, and T. G. Beach, “Postmortem interval effect on RNA and gene expression in human brain tissue,” Cell and Tissue Banking, vol. 12, no. 4, pp. 311–318, 2011.
- A. Dumitriu, C. D. Pacheco, J. B. Wilk et al., “Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study,” Human Molecular Genetics, vol. 20, no. 8, pp. 1478–1487, 2011.